{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:23:12Z","timestamp":1790392992202,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the prevalence and correlates of self\u2010reported misuse of prescribed\u2010opioid medications in the US general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In 31 068 adult participants of the National Survey on Drug Use and Health (NSDUH) 2015 and 2016 who reported using opioids in the past year, we assessed the prevalence and correlates of self\u2010reported misuse of prescribed opioids, defined as using a larger dose, more frequently, or longer than prescribed. Multivariable logistic\u2010regression models and the machine\u2010learning method of boosted regression were used to identify the correlates of misuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On the basis of weighted NSDUH estimates, of more than 89 million US adults who used prescription opioids every year, close to 3.9 million (4.4%) reported misused the prescribed medications. Prescribed\u2010opioid misuse was most strongly associated with co\u2010occurring misuse of opioids without a prescription, misuse of benzodiazepines, other drug\u2010use disorders, history of illegal activity, and psychological distress. Misuse of prescribed opioids was also strongly associated with prescription opioid\u2013use disorder, especially among those who misused more potent opioids or started misusing opioids before the current year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Misuse of prescribed opioids is associated with other high\u2010risk behaviors and adverse health outcomes. The findings call for better monitoring of opioid prescription in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4743","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T05:05:02Z","timestamp":1549429502000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Misuse of prescribed opioids in the <scp>U<\/scp>nited <scp>S<\/scp>tates"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-4043","authenticated-orcid":false,"given":"Ramin","family":"Mojtabai","sequence":"first","affiliation":[{"name":"Department of Mental Health, Bloomberg School of Public Health Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-3254","authenticated-orcid":false,"given":"Masoumeh","family":"Amin\u2010Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Bloomberg School of Public Health Johns Hopkins University  Baltimore MD USA"},{"name":"Iranian National Center for Addiction Studies Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleeka","family":"Nejat","sequence":"additional","affiliation":[{"name":"College of Dentistry University of Tennessee Health Sciences Center  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Olfson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15091179"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03052.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.05.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.05.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2014\/17\/E119"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2017.1316291"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.10.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15020262"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.01.007"},{"key":"e_1_2_9_12_1","unstructured":"MuhuriPK GfroererJC DaviesMC.Associations of nonmedical pain reliever use and initiation of heroin use in the United States. CBHSQ Data Review;2013:1\u201317.https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/DR006\/DR006\/nonmedical\u2010pain\u2010reliever\u2010use\u20102013.htm. Accessed 29 Jan 2018."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0865"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04005.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2007.00370.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12697"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1833"},{"key":"e_1_2_9_18_1","unstructured":"ChouR DeyoR DevineB et al.The effectiveness and risks of long\u2010term opioid treatment of chronic pain.Evidence report\/technology assessment No.218;2014.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK258809\/pdf\/Bookshelf_NBK258809.pdf. Accessed 20 June 2017."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5790"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4322"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.401"},{"key":"e_1_2_9_22_1","unstructured":"Center for Behavioral Health Statistics and Quality.National Survey on Drug Use and Health public use file codebook 2018;2016.https:\/\/samhda.s3\u2010us\u2010gov\u2010west\u20101.amazonaws.com\/s3fs\u2010public\/field\u2010uploads\u2010protected\/studies\/NSDUH\u20102016\/NSDUH\u20102016\u2010datasets\/NSDUH\u20102016\u2010DS0001\/NSDUH\u20102016\u2010DS0001\u2010info\/NSDUH\u20102016\u2010DS0001\u2010info\u2010codebook.pdf."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00740.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5365.867"},{"key":"e_1_2_9_25_1","volume-title":"Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys","author":"American Association for Public Opinion Research","year":"2015"},{"key":"e_1_2_9_26_1","unstructured":"Substance Abuse and Mental Health Services Administration.Reliability of key measures in the National Survey on Drug Use and Health;2010.https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/2k6ReliabilityP\/2k6ReliabilityP.pdf. Accessed 29 Jan 2018."},{"key":"e_1_2_9_27_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM\u2010IV","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2007.12.007"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/1462220042000202481"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.184"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006074"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1349"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.196"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.05.017"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2656.2008.01390.x"},{"key":"e_1_2_9_37_1","volume-title":"Classification and Regression Trees","author":"Breiman L","year":"1984"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0500500304"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203451"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.02.014"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181b91b22"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-6-46"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1371"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12403"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/01634372.2017.1327469"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.06.032"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01450.x"},{"issue":"3","key":"e_1_2_9_48_1","first-page":"S67","article-title":"American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non\u2010cancer pain: part 2\u2014guidance","volume":"15","author":"Manchikanti L","year":"2012","journal-title":"Pain Physician"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2017.s92"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j760"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.4743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.4743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.4743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:12:42Z","timestamp":1694657562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.4743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/pds.4743"],"URL":"https:\/\/doi.org\/10.1002\/pds.4743","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}