{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:09:41Z","timestamp":1790712581933,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PB\u2010PG\u20100711\u201025094"],"award-info":[{"award-number":["PB\u2010PG\u20100711\u201025094"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether inappropriate prescribing, defined by the Beers Criteria, is associated with medication\u2010related harm (MRH), hospital admission, and mortality in older adults in England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre, prospective cohort study recruited 1280 patients (median age 82 years) at hospital discharge. Patients were followed\u2010up in the community by pharmacists for 8 weeks to identify MRH (harm from adverse drug reactions, non\u2010adherence, and medication errors) and hospital admissions. One\u2010year mortality was determined using hospital records. Potentially inappropriate medications (PIMs) were determined using the 2015 version of the Beers criteria. Logistic regression was used to investigate the relationship between patients prescribed PIMs and adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seventy\u2010six patients (22%) were prescribed one or more PIMs at hospital discharge. The main PIM classes prescribed at hospital discharge were benzodiazepines and related drugs (30%) and antidepressants (27%). 1116 out of 1280 patients completed follow\u2010up and 413 (37%) experienced MRH. In 51 cases (12%), MRH was attributable to a PIM. There was no significant relationship between patients prescribed PIMs and overall MRH, hospital readmission or all\u2010cause one\u2010year mortality. Multiple PIMs at discharge was independently associated with an increased risk of ADR (OR 2.32, 95% CI 1.03\u20105.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prescribing of PIMs is common at hospital discharge of older adults in England. The 2015 Beers criteria have a limited clinical value to predict adverse outcomes following hospital discharge in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4849","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T05:47:50Z","timestamp":1563947270000},"page":"1464-1469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Do the 2015 Beers Criteria predict medication\u2010related harm in older adults? Analysis from a multicentre prospective study in the United Kingdom"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-3717","authenticated-orcid":false,"given":"Nikesh","family":"Parekh","sequence":"first","affiliation":[{"name":"Academic Department of Geriatric Medicine Brighton and Sussex Medical School  Brighton UK"},{"name":"Department of Elderly Medicine Brighton and Sussex University Hospitals NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Ali","sequence":"additional","affiliation":[{"name":"Academic Department of Geriatric Medicine Brighton and Sussex Medical School  Brighton UK"},{"name":"Department of Elderly Medicine Brighton and Sussex University Hospitals NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Graham","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakravarthi","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"Academic Department of Geriatric Medicine Brighton and Sussex Medical School  Brighton UK"},{"name":"Department of Elderly Medicine Brighton and Sussex University Hospitals NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organisation.Medication Without Harm WHO Global Patient Safety Challenge.2017."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15419"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphs.12160"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13613"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M657"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1575-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2055-2335.2013.tb00284.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04219.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0143-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0191-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002401114"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198601000-00007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S65475"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv190"},{"key":"e_1_2_12_19_1","unstructured":"Royal Pharmaceutical Society.Medicines Optimisation: helping patients to make the most of medicines.2013."},{"key":"e_1_2_12_20_1","unstructured":"National Institute for Health and Care Excellence.Medicines optimisation: the safe and effective use of medicines to enable the best possible outcomes.2015."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12178"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.215"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu029"},{"issue":"1","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40264-015-0361-1","article-title":"Vermeulen Windsant\u2010van den Tweel AMA, Egberts ACG, van den Bemt PMLA, Leendertse AJ, Hermens WAJJ, et al. 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