{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:47:01Z","timestamp":1789768021443,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1143941"],"award-info":[{"award-number":["APP1143941"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP120200814"],"award-info":[{"award-number":["LP120200814"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>People in residential aged care are at increased risk of adverse events from nonsteroidal anti\u2010inflammatory drugs (NSAIDs) due to their age and health status, but little is known about use of NSAIDs in this setting. We aimed to estimate the prevalence of NSAID use by route, differences by high\u2010risk conditions, prevalence of concurrent proton pump inhibitor (PPI) use, and prevalence of the \u201ctriple whammy\u201d combination (oral NSAID, diuretic, and angiotensin\u2010converting\u2010enzyme inhibitor or angiotensin receptor antagonist).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a dynamic cohort study using medication administration data from 68 residential aged care facilities (RACFs) during 2014 to 2017. Descriptive statistics and regression were used to estimate the proportion of residents who used NSAIDs, NSAIDs long term, NSAIDs with PPIs, and the triple whammy combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten thousand three hundred sixty\u2010seven residents were included. Two thousand four hundred fourteen (23.3%) used at least one NSAID: 756 (7.3%) used only oral, 1326 (12.8%) used only topical, and 332 (3.2%) used both topical and oral NSAIDs. One thousand five hundred forty two (14.8%) used an NSAID long term, a majority of which only used topical NSAIDs 933\/1542 (60.5%). Age, sex, and health status were associated with greater variation in long\u2010term topical use relative to oral NSAID use. A majority of oral NSAID users concomitantly used a PPI, which varied according to age, sex, and health status. Among residents with any oral NSAID use, 182\/1088 (16.7%) had triple whammy medication use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Targeted interventions to reduce NSAID use among RACF residents, to reduce triple whammy medication use, and increase PPI use for long\u2010term oral NSAID users are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4866","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T06:28:51Z","timestamp":1565159331000},"page":"1480-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["NSAID use among residents in 68 residential aged care facilities 2014 to 2017: An analysis of duration, concomitant medication use, and high\u2010risk conditions"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-1576","authenticated-orcid":false,"given":"Kimberly E.","family":"Lind","sequence":"first","affiliation":[{"name":"Centre for Health Systems and Safety Research, Australian Institute of Health Innovation Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena Z.","family":"Raban","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research, Australian Institute of Health Innovation Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-3668","authenticated-orcid":false,"given":"Andrew","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research, Australian Institute of Health Innovation Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna I.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research, Australian Institute of Health Innovation Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"24","article-title":"Recognizing the risks of chronic nonsteroidal anti\u2010inflammatory drug use in older adults","volume":"18","author":"Marcum ZA","year":"2010","journal-title":"Ann Long\u2010Term Care Off J Am Med Dir Assoc"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200119050-00002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"e_1_2_11_5_1","unstructured":"NPS MedicineWise.The Society of Hospital Pharmacists of Australia: treatments pharmacists and consumers should question.Choosing Wisely Australia;2016.http:\/\/www.choosingwisely.org.au\/recommendations\/shpa#1361. 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