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Patients with MGUS must undergo regular surveillance and testing, with few known predictors of progression. We developed an algorithm to identify MGUS patients in electronic health data to facilitate large\u2010scale, population\u2010based studies of this premalignant condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a four\u2010step algorithm using electronic health record and health claims data from men and women aged 50\u00a0years or older receiving care from a large, multispecialty medical group between 2007 and 2015. The case definition required patients to have at least two MGUS ICD\u20109 diagnosis codes within 12\u00a0months, at least one serum and\/or urine protein electrophoresis and one immunofixation test, and at least one in\u2010office hematology\/oncology visit. Medical charts for selected cases were abstracted then adjudicated independently by two physicians. We assessed algorithm validity by positive predictive value (PPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 833 people with at least two MGUS diagnosis codes; 429 (52%) met all four algorithm criteria. We randomly selected 252 charts for review, including 206 from patients meeting all four algorithm criteria. The PPV for the 206 algorithm\u2010identified charts was 76% (95% CI, 70%\u201082%). Among the 49 cases deemed to be false positives (24%), 33 were judged to have multiple myeloma or another lymphoproliferative condition, such as lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed a simple algorithm that identified MGUS cases in electronic health data with reasonable accuracy. Inclusion of additional steps to eliminate cases with malignant disease may improve algorithm performance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4912","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T01:13:51Z","timestamp":1574039631000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identifying monoclonal gammopathy of undetermined significance in electronic health data"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-4856","authenticated-orcid":false,"given":"Mara Meyer","family":"Epstein","sequence":"first","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"},{"name":"Division of Geriatric Medicine, Department of Medicine University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Saphirak","sequence":"additional","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Reliant Medical Group  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Rosmarin","sequence":"additional","affiliation":[{"name":"UpToDate  Waltham MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene","family":"Ash","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Singh","sequence":"additional","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"},{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Fisher","sequence":"additional","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"},{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda M.","family":"Birmann","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry H.","family":"Gurwitz","sequence":"additional","affiliation":[{"name":"The Meyers Primary Care Institute, a joint venture of Reliant Medical Group, Fallon Health, and the University of Massachusetts Medical School  Worcester MA USA"},{"name":"Division of Geriatric Medicine, Department of Medicine University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-194241"},{"key":"e_1_2_10_4_1","unstructured":"NooneAM HowladerN KrapchoM MillerD BrestA YuM RuhlJ TatalovichZ MariottoA LewisDR ChenHS FeuerEJ CroninKA(eds).SEER Cancer Statistics Review 1975\u20102015 National Cancer Institute. 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