{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:48:17Z","timestamp":1747151297801,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inequities between guideline\u2010recommended drugs (GRD) exposure and socioeconomic status might exist. The objective was to assess the association between a material and a social deprivation index and GRD exposure following a first acute myocardial infarction (AMI) in older adults in the province of Quebec.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study using the Quebec Integrated Chronic Disease Surveillance System. Elderly \u226566 years, hospitalized for a first AMI between January 1, 2006, and December 31, 2011 and covered by the public drug plan were identified. Exposure to GRD (i.e. simultaneous use of 1) antiplatelet, 2) beta\u2010blocker, 3) lipid\u2010lowering and 4) angiotensin\u2010converting enzyme inhibitor or angiotensin II receptor blocker drugs) was assessed 30 and 365 days following hospital discharge. Associations between deprivation index and GRD exposure were estimated with log\u2010binomial regressions adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to GRD was 52.2% and 48.0%, 30 and 365 days after hospital discharge, respectively. No statistically significant association was observed in multivariate analysis for both time points. Thirty days post hospital discharge, adjusted prevalence ratio of non\u2010exposure to GRD was 0.98 (95% confidence interval [CI]: 0.95\u20101.02) for most materially deprived vs. least deprived and 1.04 (95% CI: 0.99\u20101.08) for most socially deprived vs. least deprived. Similar results were observed for 365 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to GRD after a first urgent AMI among older adults insured by the public drug plan in the province of Quebec is relatively low. Reasons and risk groups for this low exposure should be studied to improve secondary prevention. However, results suggest equitable access to GRD, regardless of deprivation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4915","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T04:25:03Z","timestamp":1575433503000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exposure to guideline\u2010recommended drugs after a first acute myocardial infarction in older adults: does deprivation matter?"],"prefix":"10.1002","volume":"29","author":[{"given":"Adjo Enyonam","family":"Akator","sequence":"first","affiliation":[{"name":"Faculty of pharmacy, 1050 avenue de la M\u00e9decine Universit\u00e9 Laval  Quebec Canada"},{"name":"Axe sant\u00e9 des populations et pratiques optimales en sant\u00e9 Centre de recherche du CHU de Quebec  1050 chemin Ste\u2010Foy, Quebec City Quebec 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sant\u00e9 des populations et pratiques optimales en sant\u00e9 Centre de recherche du CHU de Quebec  1050 chemin Ste\u2010Foy, Quebec City Quebec Canada"},{"name":"Department of nursing Universit\u00e9 du Qu\u00e9bec \u00e0 Rimouski  1595 boulevard Alphonse\u2010Desjardins, L\u00e9vis Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-7550","authenticated-orcid":false,"given":"Line","family":"Gu\u00e9nette","sequence":"additional","affiliation":[{"name":"Faculty of pharmacy, 1050 avenue de la M\u00e9decine Universit\u00e9 Laval  Quebec Canada"},{"name":"Axe sant\u00e9 des populations et pratiques optimales en sant\u00e9 Centre de recherche du CHU de Quebec  1050 chemin Ste\u2010Foy, Quebec City Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"volume-title":"Report from the Canadian Chronic Disease Surveillance System: Heart 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