{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:37:39Z","timestamp":1783953459038,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to describe the genetic and clinical risk factors associated with phenytoin\u2010induced cutaneous adverse drug reactions (PHT\u2010induced cADRs) in Thai patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective case\u2010control study was conducted among 88 PHT\u2010 cADRs (25 SJS\/TEN, 37 DRESS\/DIHS and 26 MPE) compared to 70 PHT\u2010tolerant controls during 2008\u20102017. Genotyping was performed by Taqman RT\u2010PCR (<jats:italic>EPHX1<\/jats:italic> 337\u2009T\u2009&gt;\u2009C, <jats:italic>EPHX1<\/jats:italic> 416A\u2009&gt;\u2009G and <jats:italic>CYP2C9*3<\/jats:italic>), pyrosequencing (<jats:italic>UGT1A1*28<\/jats:italic>, <jats:italic>UGT1A1*6<\/jats:italic>) and polymerase chain reaction\u2010sequence\u2010specific oligonucleotide probe (<jats:italic>HLA\u2010B<\/jats:italic>). Chi\u2010squared test and binary logistic regression were used to identify factors associated with PHT\u2010cADRs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis showed that <jats:italic>HLA\u2010B*46:01<\/jats:italic> was significantly associated with all PHT\u2010induced cADRs (OR 2.341; 95% CI, 1.078\u20105.084; <jats:italic>P<\/jats:italic> = .032). Age of \u226560\u2009years showed a significant association with PHT\u2010induced SJS\/TEN (OR 3.600; 95% CI, 1.214\u201010.672; <jats:italic>P<\/jats:italic> = .021). <jats:italic>CYP2C9*3<\/jats:italic> was almost reaching statistically associated with an increased risk of PHT\u2010induced SJS\/TEN (OR 4.800; 95% CI, 0.960\u201023.990; <jats:italic>P<\/jats:italic> = .056). While <jats:italic>HLA\u2010B*56:02\/04<\/jats:italic> was found to have a significant association with PHT\u2010induced DRESS\/DIHS (OR 29.312; 95% CI, 1.213\u2010707.994; <jats:italic>P<\/jats:italic> = .038). Moreover, female gender and <jats:italic>HLA\u2010B*40:01<\/jats:italic> were associated with an increased risk of PHT\u2010induced MPE at OR 5.734; 95% CI, 0.910\u201058.351; <jats:italic>P<\/jats:italic> = .042 and OR 3.647; 95% CI, 1.193\u201011.147; <jats:italic>P<\/jats:italic> = .023, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both clinical (advanced age, female gender) and genetic factors (<jats:italic>HLA\u2010B*46:01<\/jats:italic>, <jats:italic>CYP2C9*3<\/jats:italic>, <jats:italic>HLA\u2010B*56:02\/04<\/jats:italic> and <jats:italic>HLA\u2010B*40:01<\/jats:italic>) contributed to the risk of PHT\u2010induced cADRs. Further studies with larger sample size may be warranted to confirm these findings and also the influence of <jats:italic>EPHX1<\/jats:italic> gene.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.4979","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T13:25:05Z","timestamp":1583414705000},"page":"565-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Genetic and clinical risk factors associated with phenytoin\u2010induced cutaneous adverse drug reactions in Thai population"],"prefix":"10.1002","volume":"29","author":[{"given":"Chonlaphat","family":"Sukasem","sequence":"first","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital  Bangkok 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