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Persons aged 70\u2010110\u2009years with incident PD from April 2002\u2010March 2013. Controls were randomly selected from persons with no previous diagnosis of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 of the top 50 drugs were deemed feasible for pharmacoepidemiologic analysis, of which seven were significantly associated with incident PD after adjustment, with five of these seven associated with a decreased odds of PD. Methylxanthine drugs pentoxifylline (OR, 0.72; 95% CI, 0.59\u20100.89) and theophylline (OR, 0.77; 95% CI, 0.66\u20100.91), and the corticosteroid dexamethasone (OR, 0.72; 95% CI, 0.61\u20100.85) were associated with decreased odds of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate the feasibility of this approach to focus the search for disease\u2010modifying drugs. Corticosteroids and methylxanthines should be further investigated as potential disease\u2010modifyingdrugs in PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5015","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T06:32:08Z","timestamp":1589524328000},"page":"864-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Identifying drugs with disease\u2010modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-6939","authenticated-orcid":false,"given":"Laura C.","family":"Maclagan","sequence":"first","affiliation":[{"name":"ICES, Life Stage Research Program  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-7845","authenticated-orcid":false,"given":"Naomi P.","family":"Visanji","sequence":"additional","affiliation":[{"name":"Edmond J Safra Program in Parkinson Disease Toronto Western Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"ICES, Life Stage Research Program  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Tadrous","sequence":"additional","affiliation":[{"name":"ICES, Life Stage Research Program  Toronto Ontario Canada"},{"name":"Women's College Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix M. 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