{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:33:41Z","timestamp":1776868421911,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["678033"],"award-info":[{"award-number":["678033"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL098048\u20101"],"award-info":[{"award-number":["T32HL098048\u20101"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003506","name":"Helse- og Omsorgsdepartementet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the validity of dispensed prescription to classify exposure to medications used episodically during pregnancy, and to explore individual trajectories of episodic medication use across pregnancy, using triptans for migraine as the motivating example.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared self\u2010reported triptan use during pregnancy in The Norwegian Mother, Father and Child Cohort Study (MoBa) to dispensed prescriptions in The Norwegian Prescription Database and calculated Cohen's kappa coefficient (\u03ba), sensitivity, specificity and predictive values using MoBa as reference standard. We used group\u2010based trajectory modeling to estimate exposure trajectories in MoBa according to probability of triptan use across pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 6051 pregnancies where mothers filled at least one triptan prescription or reported migraine or triptan use in the 6\u2009months before or during pregnancy. Sensitivity of prescribed triptans during pregnancy was low (39.1%), but specificity was quite high (95.4%). Agreement between the two data sources was fair (\u03ba 0.36). We identified three trajectory groups in MoBa including constant\u2010high, decreasing\u2010medium and decreasing\u2010low probability of triptan use across pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using dispensed prescriptions rather than self\u2010report to classify exposure to triptans during pregnancy is likely to result in substantial under\u2010estimation of exposure. In this study, traditional definitions of ever\u2010exposed vs never\u2010exposed failed to capture variations in drug utilization during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5089","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T01:18:45Z","timestamp":1596503925000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Modeling exposures of medications used episodically during pregnancy: Triptans as a motivating example"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-371X","authenticated-orcid":false,"given":"Gerd\u2010Marie Eskerud","family":"Harris","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Research Initiative, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-2641","authenticated-orcid":false,"given":"Mollie","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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