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We used several indices such as reporting odds ratio (ROR) to assess disproportionality in pharmacovigilance data, time\u2010to\u2010onset analysis using Weibull shape parameters, and the association rule mining technique to evaluate possible risk factors between variables in the spontaneous reporting system database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The JADER database contained 534\u2009688 reports from April 2004 to June 2018. The RORs of pneumonitis including interstitial lung disease for nivolumab, pembrolizumab, and ipilimumab were 7.02 (95% confidence interval: 6.55\u20107.52), 9.08 (8.28\u20109.97), and 1.74 (1.27\u20102.38), respectively. The median onsets (quartiles, 25\u201075%) of myocarditis caused by nivolumab and pembrolizumab were 28.0 (15.5\u201060.5) and 18.0 (13.0\u201044.5) days, respectively. Co\u2010therapy with nivolumab and ipilimumab may be associated with irAEs in several categories as per the association rule mining analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrated a potential risk of irAEs associated with ICIs, based on RORs and time\u2010to\u2010onset analysis. 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