{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:09:38Z","timestamp":1788260978909,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Clinical Practice Research Datalink (CPRD) now provides a new medical record database, CPRD Aurum. This is the second of several studies being undertaken to assess the quality of CPRD Aurum data for research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included patients aged 20+, with at least one lab test result of any type from a random sample of 50\u2009000 patients in CPRD Aurum. We assessed whether diagnosis codes for type 2 diabetes, hyperlipidemia, and iron deficiency or unspecified anemia were accompanied by supporting codes including lab results and treatments (\n                      <jats:italic>correctness<\/jats:italic>\n                      ) and whether lab results, treatments, or other codes indicate a missing diagnosis record (\n                      <jats:italic>completeness<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 37\u2009502 patients in CPRD Aurum,\n                      <jats:italic>correctness<\/jats:italic>\n                      of type 2 diabetes, hyperlipidemia, and anemia diagnoses was high (99%, 93%, and 97%, respectively).\n                      <jats:italic>Completeness<\/jats:italic>\n                      was only high for type 2 diabetes (94%\u201098%); completeness for hypercholesterolemia and anemia diagnoses was modest even when the presence of treatments and lab results indicated the conditions were likely present (51%\u201059% and 58%\u201070%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that for studies of type 2 diabetes, hyperlipidemia, and iron deficiency or unspecified anemia, the diagnosis code is likely to be correct where present. However, a significant proportion of cases of hyperlipidemia or anemia will be missed if only diagnosis codes are used to select patients with these conditions. Researchers should consider using treatments, supporting codes, and, when available, lab data to supplement diagnosis codes and enhance case capture when including these conditions in studies using CPRD Aurum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.5135","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:28:23Z","timestamp":1601303303000},"page":"1456-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["<scp>CPRD<\/scp>\n                    Aurum database: Assessment of data quality and completeness of three important comorbidities"],"prefix":"10.1002","volume":"29","author":[{"given":"Rebecca","family":"Persson","sequence":"first","affiliation":[{"name":"Boston Collaborative Drug Surveillance Program  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vasilakis\u2010Scaramozza","sequence":"additional","affiliation":[{"name":"Boston Collaborative Drug Surveillance Program  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina Wilcox","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Boston Collaborative Drug Surveillance Program  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Sponholtz","sequence":"additional","affiliation":[{"name":"Boston Collaborative Drug Surveillance Program  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Williams","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Myles","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-1067","authenticated-orcid":false,"given":"Susan S.","family":"Jick","sequence":"additional","affiliation":[{"name":"Boston Collaborative Drug Surveillance Program  Lexington Massachusetts USA"},{"name":"Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6779.766"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.5.686.32205"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03537.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp10X483562"},{"key":"e_1_2_9_6_1","unstructured":"Medicines & Healthcare Products Regulatory Agency. Clinical Practice Research Datalink [Internet].www.CPRD.com. Accessed April 1 2020."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04248-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000681"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz034"},{"key":"e_1_2_9_11_1","unstructured":"NHS Digital. SNOMED CT [Internet].https:\/\/digital.nhs.uk\/services\/terminology-and-classifications\/snomed-ct. Accessed April 1 2020"},{"key":"e_1_2_9_12_1","unstructured":"NHS Digital. Read codes [Internet].https:\/\/digital.nhs.uk\/services\/terminology-and-classifications\/read-codes. Accessed April 1 2020"},{"key":"e_1_2_9_13_1","unstructured":"NHS Business Services Authority. Dictionary of medicines and devices (dm+d) [Internet].https:\/\/www.nhsbsa.nhs.uk\/pharmacies-gp-practices-and-appliance-contractors\/dictionary-medicines-and-devices-dmd. Accessed April 1 2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4996"},{"key":"e_1_2_9_15_1","unstructured":"NHS Digital. Hospital Episode Statistics (HES) [Internet].https:\/\/digital.nhs.uk\/data-and-information\/data-tools-and-services\/data-services\/hospital-episode-statistics. Accessed April 1 2020"},{"key":"e_1_2_9_16_1","unstructured":"NHS Digital. Quality Outcomes Framework (QOF) [Internet].https:\/\/digital.nhs.uk\/data-and-information\/data-tools-and-services\/data-services\/general-practice-data-hub\/quality-outcomes-framework-qof. Accessed April 1 2020"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:10:46Z","timestamp":1692843046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/pds.5135"],"URL":"https:\/\/doi.org\/10.1002\/pds.5135","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}