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Variables: age, sex, sociodemographic variables, number of drugs, kidney and liver function and MRPs (duplicate therapy, drug\u2010drug interactions, potentially inappropriate medications [PIMs] and drugs contraindicated in chronic kidney disease and in liver diseases). Unconditional logistic regression models were used to identify the factors associated with MRPs in patients with multimorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>916\u2009619 older people were included and 853\u2009085 of them met the criteria for multimorbidity. Median age was 75\u2009years and 57.7% of them were women. High percentages of MRPs were observed: PIMs (62.8%), contraindicated drugs in chronic kidney disease (12.1%), duplicate therapy (11.1%), contraindicated drugs in liver diseases (4.2%), and drug\u2010drug interactions (1.0%). These numbers were higher in the subgroup of patients with \u226510 diseases. The most common PIMs were connected to drugs that increase the risk of fall (66.8%), antiulcer agents without criteria for gastroprotection (40.6%), and the combination of drugs with anticholinergic effects (39.7%). In the multivariate analysis, the variables associated with all MRPs among the patients with multimorbidity were the number of drugs and the number of visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The coexistence of multimorbidity and polypharmacy is associated with an elevated risk of MRPs in older people. Medication safety for older patients constitutes a pressing concern for health services.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5149","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T16:13:59Z","timestamp":1602087239000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Medication\u2010related problems in older people in Catalonia: A real\u2010world data study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-0912","authenticated-orcid":false,"given":"Amelia","family":"Troncoso\u2010Mari\u00f1o","sequence":"first","affiliation":[{"name":"\u00c0rea del Medicament i Servei de Farm\u00e0cia, Ger\u00e8ncia Territorial de Barcelona Institut Catal\u00e0 de la Salut Barcelona Spain"},{"name":"Department of Clinical Sciences University of Barcelona and IDIBELL. 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