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Here, we estimated the association between THRT during pregnancy and the first trimester and these developmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was based on the Norwegian Mother, Father, and Child Cohort Study (MoBa) and other national registries. We included mother\u2013child pairs exposed to THRT during pregnancy (<jats:italic>n<\/jats:italic> =\u2009663), after delivery (<jats:italic>n<\/jats:italic> =\u2009728), or unexposed (<jats:italic>n<\/jats:italic> =\u200928\u2009040). Exposure to THRT was defined according to filled prescriptions. Child outcomes, presented as <jats:italic>T<\/jats:italic>\u2010score differences, were parent\u2010reported using the Ages and Stages Questionnaire, Strengths and Difficulties Questionnaire, and Child Behavior Checklist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 29\u2009431 mother\u2013child pairs, 2.3% were prenatally exposed to THRT. We found no difference between prenatally exposed and unexposed children in regards to gross motor function (<jats:italic>\u03b2<\/jats:italic>: 0.17, 95% CI \u22121.19, 1.54), fine motor function (<jats:italic>\u03b2<\/jats:italic>: \u22120.17, 95% CI \u22121.14, 0.80), communication (<jats:italic>\u03b2<\/jats:italic>: \u22120.31, 95% CI \u22121.58, 0.96), externalizing (<jats:italic>\u03b2<\/jats:italic>: \u22120.03, 95% CI \u22121.07, 1.01), internalizing (<jats:italic>\u03b2<\/jats:italic>: 0.89, 95% CI \u22120.20, 1.97), or social behaviors (<jats:italic>\u03b2<\/jats:italic>: \u22120.04, 95% CI \u22120.92, 0.84). Somatic complaints were higher in THRT\u2010exposed children (<jats:italic>\u03b2<\/jats:italic>: 0.98, 95% CI 0.08, 1.87), and children whose mothers were exposed after delivery had more sleep problems than unexposed children (<jats:italic>\u03b2<\/jats:italic>: 0.99, 95% CI 0.24, 1.74).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children prenatally exposed to THRT have developmental outcomes as positive as unexposed children on motor function, communication, and behavior. The association with somatic complaints and sleep were not clinically relevant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5184","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T11:37:54Z","timestamp":1607773074000},"page":"716-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-1484","authenticated-orcid":false,"given":"Sophie","family":"van den Broek","sequence":"first","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"},{"name":"Department for Health Evidence, Radboud Institute for Health Sciences Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-3183","authenticated-orcid":false,"given":"Angela","family":"Lupattelli","sequence":"additional","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-3476","authenticated-orcid":false,"given":"Anna S.","family":"Frank","sequence":"additional","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-6399","authenticated-orcid":false,"given":"Line Sm\u00e5stuen","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Environmental Exposure and Epidemiology Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-2918","authenticated-orcid":false,"given":"Hedvig","family":"Nordeng","sequence":"additional","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"},{"name":"Department of Child Health and Development Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,27]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/tog.12161","article-title":"Thyroid dysfunction and reproductive health","volume":"17","author":"Jefferys A","year":"2015","journal-title":"Obstet Gynaecol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.3.0300"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2149"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.03.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.09.070"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219778"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0318"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.66"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606205"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03743.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00639.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410801"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb18424.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/426427"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318276ccd3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03102.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw029"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl170"},{"key":"e_1_2_10_22_1","unstructured":"health Niop.Norwegian Mother Father and Child Cohort Study. 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