{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T21:33:17Z","timestamp":1774819997189,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["study 206406\/HO\u201015\u201016210"],"award-info":[{"award-number":["study 206406\/HO\u201015\u201016210"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the feasibility of using Clinical Practice Research Datalink (CPRD) data for identifying populations of patients with chronic obstructive pulmonary disease (COPD) eligible for a hypothetical pragmatic trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective multidatabase cohort study using CPRD primary care and linked secondary care data to describe the characteristics of populations of patients with COPD. Patients' demographic and lifestyle factors, comorbidity profile, spirometry measurements and treatment changes were evaluated, as was the distribution of follow\u2010up time and types of losses during follow\u2010up. Characteristics were evaluated using descriptive statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 322\u2009991 patients from 1148 primary care practices in the United Kingdom across two CPRD primary care databases, CPRD GOLD and CPRD Aurum, were potentially eligible to participate in a hypothetical trial using CPRD, starting on 31 December 2017. Patients with COPD in CPRD GOLD and CPRD Aurum were comparable in terms of age (median age 70 vs. 68\u2009years), gender (50% vs. 52% male), disease severity (e.g., 25% vs. 24% Medical Research Council [MRC] dyspnoea score grades 3\u20135) and history of respiratory conditions (e.g., 43% vs. 38% asthma). High proportions of patients with COPD in CPRD GOLD and CPRD Aurum were available on 31 December 2012 for follow\u2010up at 1, 2, and 5\u2009years (92%, 85% and 67%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients and data from CPRD GOLD and CPRD Aurum were comparable across key aspects relevant to COPD trials. A pragmatic trial using CPRD to recruit patients with COPD is scientifically feasible.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5188","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T04:43:15Z","timestamp":1609130595000},"page":"472-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Feasibility of using Clinical Practice Research Datalink data to identify patients with chronic obstructive pulmonary disease to enrol into real\u2010world trials"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-6656","authenticated-orcid":false,"given":"Gema","family":"Requena","sequence":"first","affiliation":[{"name":"Respiratory Epidemiology GlaxoSmithKline  Brentford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Wolf","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-6292","authenticated-orcid":false,"given":"Rachael","family":"Williams","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dedman","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Quint","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology, Occupational Medicine and Public Health National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarita","family":"Murray\u2010Thomas","sequence":"additional","affiliation":[{"name":"Clinical Practice Research Datalink Medicines and Healthcare Products Regulatory Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne M.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology GlaxoSmithKline  Brentford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510059"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774512450097"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12559"},{"key":"e_1_2_10_5_1","unstructured":"Academy of Medical Sciences. Next steps for using real world evidence.https:\/\/acmedsci.ac.uk\/file-download\/7021031. Accessed 15 June 2020."},{"key":"e_1_2_10_6_1","unstructured":"CPRD. Clinical practice research Datalink.https:\/\/cprd.com\/home. Accessed 15 June 2020."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020738"},{"key":"e_1_2_10_8_1","unstructured":"CPRD. Primary care data for public health research.https:\/\/cprd.com\/primary-care. Accessed 15 June 2020."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1381-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.07.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005540"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151357"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41030-019-0092-z"},{"key":"e_1_2_10_14_1","unstructured":"GOLD. Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease. 2006.https:\/\/www.who.int\/respiratory\/copd\/GOLD_WR_06.pdf. Accessed 15 June 2020."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-018-0089-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S190086"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00186.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.49"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608033"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2018-000339"},{"issue":"43","key":"e_1_2_10_22_1","first-page":"1","article-title":"The opportunities and challenges of pragmatic point\u2010of\u2010care randomised trials using routinely collected electronic records: evaluations of two exemplar trials","volume":"18","author":"Staa TP","year":"2014","journal-title":"Health Technol Assess"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-0596-x"},{"key":"e_1_2_10_24_1","unstructured":"NHS.NHS Resolution\u2010 Annual report and accounts 2018\/19; 2019."}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T23:26:39Z","timestamp":1693697199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/pds.5188"],"URL":"https:\/\/doi.org\/10.1002\/pds.5188","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,9]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}