{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:37:43Z","timestamp":1780468663365,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R56AG061813\u201001"],"award-info":[{"award-number":["1R56AG061813\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Prescribing cascades occur when a physician prescribes a new drug to address the side\u2010effect of another drug. Persons with Alzheimer's disease and related dementias (ADRD) are at increased risk for prescribing cascades. Our objective was to develop an approach to estimating the proportion of calcium channel blocker\u2010diuretic (CCB\u2010diuretic) prescribing cascades among persons with ADRD in two U.S. health plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients aged \u226550 on January 1, 2017, dispensed a drug to treat ADRD in the 365\u2010days prior to\/on cohort entry date. Patients had medical\/pharmacy coverage for 1\u2009year before and through cohort entry. We excluded individuals with an institutional stay encounter in the 45\u2009days prior to cohort entry and censored patients based on: disenrollment from coverage, death, or end of data. We identified incident and prevalent CCB use in the 183\u2010days following cohort entry, and identified subsequent incident diuretic use among incident and prevalent CCB\u2010users within 365\u2010days from cohort entry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 121\u2009538 eligible patients. Approximately 62% were female, with a mean age of 79.5 (SD \u00b18.6). Overall 2.1% of the cohort experienced a prevalent CCB\u2010diuretic prescribing cascade with 1586 incident diuretic\u2010users among 36\u2009462 prevalent CCB\u2010users (4.3%, 95% CI 4.1\u20134.6%]); and there were161 incident diuretic\u2010users among 3304 incident CCB\u2010users (4.9%, 95% CI 4.2\u20135.7%) (incident CCB\u2010diuretic cascade).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe an approach to identify prescribing cascades in persons with ADRD, which can be used to assess the proportion of prescribing cascades in large cohorts. We determined the proportion of CCB\u2010diuretic prescribing cascades was low.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5230","type":"journal-article","created":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T08:04:33Z","timestamp":1615709073000},"page":"1066-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Identifying prescribing cascades in Alzheimer's disease and related dementias: The calcium channel <scp>blocker\u2010diuretic<\/scp> prescribing cascade"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-941X","authenticated-orcid":false,"given":"Sonal","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2761","authenticated-orcid":false,"given":"Noelle M.","family":"Cocoros","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School \/ Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-2881","authenticated-orcid":false,"given":"Kevin","family":"Haynes","sequence":"additional","affiliation":[{"name":"HealthCore, Inc. Wilmington  Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinit P.","family":"Nair","sequence":"additional","affiliation":[{"name":"Humana Healthcare Research Inc. (Humana)  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Harkins","sequence":"additional","affiliation":[{"name":"Humana Healthcare Research, Inc. (Humana)  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Rochon","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School \/ Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Dashevsky","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School \/ Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School \/ Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Mazor","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bloomstone","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Anzuoni","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybil L.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry H.","family":"Gurwitz","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School &amp; Meyers Primary Care Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7115.1096"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.03.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091496"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12906"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.7.808"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.10.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.7087"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0281-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18425"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2018.06.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15800"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283472643"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.016"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:19:30Z","timestamp":1692850770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/pds.5230"],"URL":"https:\/\/doi.org\/10.1002\/pds.5230","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}