{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:49:03Z","timestamp":1747151343199,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Opioid use after surgical repair for pelvic organ prolapse (POP) is intended for short\u2010term post\u2010operative pain. This study compared the incidence of opioid prescribing in women undergoing POP transabdominal repair with mesh and transvaginal native tissue repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort of women undergoing POP transabdominal repair with mesh or transvaginal native tissue repair, was derived from a 10% random sample of enrollees from 2007 to 2015 within the IQVIA PharMetrics\u00ae Plus Database. Primary outcomes were any prescription of opioids and cumulative days of opioids prescribed in the 14\u2013 180\u2009days following surgical intervention. Inverse probability of treatment weights controlled for observed baseline confounders. Any opioid prescription was estimated using logistic regression and generalized linear regression for cumulative days of opioids prescribed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort of 49\u2009052 women who underwent POP surgical repair included 46\u2009813 women with transvaginal native tissue repair and 2239 women with transabdominal repair with mesh. Women with a transabdominal repair with mesh had a 1.19 (95%CI: 1.09\u20131.31) significantly higher odds of receiving an opioid prescription than women with transvaginal native tissue repair. Post\u2010operatively, over 29% of women received opioid prescriptions. Mean cumulative days of post\u2010surgical opioid prescribing was 32.2 (SD\u00a0=\u00a043.1), and was not statistically different between groups. Thirteen percent of women were prescribed opioids for 90\u2009days or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women undergoing POP with transabdominal mesh are more likely to receive prescriptions for opioids after surgery compared to transvaginal native tissue repair. Treatment plans that address pain while mitigating the risks associated with prolonged opioid prescribing should be employed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5239","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T11:21:21Z","timestamp":1617362481000},"page":"993-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Opioid prescribing and risks among commercially insured women undergoing pelvic organ prolapse repair"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-2174","authenticated-orcid":false,"given":"Laura E.","family":"Gressler","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"dosReis","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medical College\/New York Presbyterian  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/mi.2011.011108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.038"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f73729"},{"key":"e_1_2_11_6_1","unstructured":"Food and Drug Administration.Urogynecologic Surgical Mesh Implants;2019.https:\/\/www.fda.gov\/medical-devices\/implants-and-prosthetics\/urogynecologic-surgical-mesh-implants. Accessed April 29 2019."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012509.pub2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.12.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.234"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.11m01326"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-6-200209170-00010"},{"key":"e_1_2_11_13_1","unstructured":"IQVIA.IQVIA PharMetrics\u00ae Plus Fact Sheet;2020.https:\/\/www.iqvia.com\/-\/media\/iqvia\/pdfs\/library\/fact-sheets\/iqvia-pharmetrics-plus---us-fact-sheet.pdf?_=1616024336108. Accessed March 17 2021."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00218-4"},{"key":"e_1_2_11_15_1","unstructured":"United States Census Bureau.Census Regions and Divisions of the United States.https:\/\/www2.census.gov\/geo\/pdfs\/maps-data\/maps\/reference\/us_regdiv.pdf."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2017.04.170112"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0504"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.7222"},{"volume-title":"Textbook of Substance Abuse Treatment","year":"2014","author":"Galanter M","key":"e_1_2_11_19_1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj149"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215584401"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_11_24_1","first-page":"1","article-title":"A unified approach to measuring the effect size between two groups using SAS\u00ae","volume":"335","author":"Yang D","year":"2012","journal-title":"SAS Global Forum"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_11_26_1","first-page":"1809","article-title":"Sensitivity analysis in observational studies","volume":"4","author":"Rosenbaum PR","year":"2005","journal-title":"Encycl Stat Behav Sci"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1251"},{"key":"e_1_2_11_28_1","unstructured":"National Institue on Drug Abuse (NIDA).Overdose Death Rates;2019.https:\/\/www.drugabuse.gov\/related-topics\/trends-statistics\/overdose-death-rates. Accessed November 10 2019."},{"key":"e_1_2_11_29_1","unstructured":"OwensPL BarrettML WeissAJ WashingtonRE KronickR.Hospital Inpatient Utilization Related to Opioid Overuse Among Adults 1993\u20132012: Statistical Brief #177. In: Rockville MD;2006."},{"key":"e_1_2_11_30_1","unstructured":"White House.Ending America's Opioid Crisis;2018.https:\/\/www.whitehouse.gov\/opioids\/. Accessed November 10 2019."},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.3298"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.5452"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001993"},{"key":"e_1_2_11_34_1","unstructured":"Food and Drug Administration.Urogynecologic Surgical Mesh: Update on the Safety and Effectiveness of Transvaginal Placement for Pelvic Organ Prolapse;2011.https:\/\/www.fda.gov\/downloads\/medicaldevices\/safety\/alertsandnotices\/ucm262760.pdf"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13158"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2685"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3446-9"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:18:47Z","timestamp":1692850727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/pds.5239"],"URL":"https:\/\/doi.org\/10.1002\/pds.5239","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"type":"print","value":"1053-8569"},{"type":"electronic","value":"1099-1557"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}