{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:40:52Z","timestamp":1767850852056,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the validity of International Classification of Diseases, 10th Revision, (ICD\u201010) code\u2010based algorithms for herpes zoster (HZ) in the electronic medical record (EMR) of a large, integrated pediatric healthcare network and to examine baseline demographics and chronic comorbidities associated with HZ in a representative pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the electronic charts of all patients with a single ICD\u201010 for HZ (B02.xx) as their primary or secondary diagnosis in the EMR of the Children's Hospital of Philadelphia (CHOP) healthcare network from January 2010\u2013March 2019. The positive predictive value (PPV) for a single code for HZ was calculated and alternative algorithms were examined to determine which method resulted in the highest PPV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PPV for a single ICD\u201010 code was 91.7% (95% CI 80.8\u201395.4) for definitive and\/or probable cases of HZ and 63.9% (95% CI 53.4%\u201375.5%) for definitive cases alone. Adding a prescription for an antiviral did not improve the PPV. However, adding a new code for rash entered within 1\u00a0week of the HZ code increased the PPV to 100% for definitive and\/or probable cases but with substantial loss of sensitivity. A high proportion of children with HZ who required inpatient hospitalization had chronic disease (70%) and were on systemic immunomodulatory therapy (50%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HZ can be identified with a high PPV in electronic medical records of children using ICD\u201010 code alone. These findings lay the foundation for future pharmacoepidemiologic research to better understand risk factors for HZ infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5264","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T19:18:47Z","timestamp":1620501527000},"page":"1162-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation of coding algorithms for the identification of herpes zoster among children"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-7376","authenticated-orcid":false,"given":"Beth H.","family":"Rutstein","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania 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