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This study ascertained the performance of International Classification of Diseases (ICD) codes for AIH, and developed and validated a novel algorithm that reliably identifies patients with AIH in health administrative data and claims.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study of patients with \u22651 inpatient or\u2009\u22652 outpatient ICD codes for AIH between 2008 and 2019 at a single health system. In a random sample of 250 patients, definite or probable AIH was determined using the Simplified AIH score, Revised AIH score or expert adjudication. The positive predictive value (PPV) was obtained. Variations of this base algorithm were evaluated using additional criteria to increase its performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 250 patients, 143 (57.2%) patients had sufficient records available for review. The PPV of the base algorithm was 77.6% (95% CI: 69.9\u201384.2%). Exclusion of patients with \u22651 ICD code for primary biliary cholangitis or primary sclerosing cholangitis yielded a PPV of 89.7% (95% CI: 82.8\u201394.6%). Further exclusion of patients with recent immune checkpoint inhibitor therapy increased the PPV to 92.9% (95% CI: 86.5\u201396.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of ICD codes for AIH alone are insufficient to reliably identify patients with AIH in health administrative data and claims. Our proposed algorithm that includes additional diagnostic and medication\u2010related coding criteria demonstrates excellent performance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5291","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:48:56Z","timestamp":1620823736000},"page":"1168-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Validating a novel algorithm to identify patients with autoimmune hepatitis in an administrative database"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-0193","authenticated-orcid":false,"given":"Therese","family":"Bittermann","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology &amp; Hepatology University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics, Epidemiology &amp; Informatics University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology &amp; Hepatology University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics, Epidemiology &amp; Informatics University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology &amp; Hepatology University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics, Epidemiology &amp; Informatics University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Health and Liver Disease University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Health and Liver Disease University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.10.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4675-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06019.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2018.1482884"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.3.319"},{"key":"e_1_2_11_8_1","unstructured":"GovTrack.us.H.R. 34 \u2010 114th Congress: 21st Century Cures Act. 2015;https:\/\/www.govtrack.us\/congress\/bills\/114\/hr34 Accessed April 22 2021."},{"key":"e_1_2_11_9_1","unstructured":"U.S. Food & Drug Administration.Framework for FDA's Real World Evidence Program; 2018.https:\/\/www.fda.gov\/media\/120060\/download. 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