{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:46:35Z","timestamp":1693309595021},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001594","name":"Dysautonomia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Patients with the autosomal recessive disorder of familial dysautonomia typically exhibit exacerbated adverse side effects to many common drugs. We aimed to catalog these adverse effects \u2013 with a focus on common drugs that are frequently administered to FD patients and compare their incidences to those within the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data of 595 FD patients from an international database with information on drugs received and adverse effects. To investigate the molecular causes of reported differences in drug responses in FD patients, we used expression microarrays to compare the mRNA expression profiles in peripheral blood leukocytes of FD patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and healthy individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several drug classes, including cholinergics, anti\u2010cholinergics, anti\u2010convulsants, methylxanthines, SSRIs, and antibiotics caused either unreported symptoms or elevated rates of adverse events in FD patients. FD patients experienced different or more frequent adverse side effects than the general population in 31\/123 drugs. These side effects included blood cell dyscrasias, amenorrhea, gastrointestinal bleeding, and bronchospasm. New findings include enhanced reaction of FD patients to H2 antagonist agents and to serotonin receptor agonists. We also detected eight genes differentially expressed between FD patients and healthy individuals that may underlie the differential drug responses of FD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We provide evidence that suggests the use of several common drugs should be discontinued or reduced in FD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5326","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T12:09:07Z","timestamp":1625918947000},"page":"128-140","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncommon side effects of common drugs in patients with familial dysautonomia"],"prefix":"10.1002","volume":"31","author":[{"given":"Liat","family":"Perl","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hadassah University Hospital, Mount Scopus, Hebrew University\u2010Hadassah Medical School  Jerusalem Israel"},{"name":"Pediatric Endocrinology and Diabetes Unit, Dana\u2010Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hakimian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hadassah University Hospital, Mount Scopus, Hebrew University \u2013 Hadassah Medical School  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Channa","family":"Maayan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hadassah University Hospital, Mount Scopus, Hebrew University\u2010Hadassah Medical School  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rekhtman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hadassah University Hospital, Mount Scopus, Hebrew University\u2010Hadassah Medical School  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elchanan","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hadassah University Hospital, Mount Scopus, Hebrew University \u2013 Hadassah Medical School  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mali","family":"Salmon\u2010Divon","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Mark","family":"Sapozhnikov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cheishvili","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Ariel University  Ariel Israel"},{"name":"Gerald Bronfman Department of Oncology McGill University  Montreal Quebec Canada"},{"name":"HKG Epitherapeutics  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.3.4.468"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10499"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1987.tb03334.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.4.561"},{"key":"e_1_2_8_6_1","first-page":"358","article-title":"Ocular responses to autonomic drugs in familial Dysautonomia","volume":"4","author":"Smith AA","year":"1965","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197509000-00004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2005.12.001"},{"key":"e_1_2_8_9_1","unstructured":"CannonWB RosenbluethA.The supersensitivity of denervated structures. 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