{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:02:13Z","timestamp":1784383333314,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine use of sedating medications around the time of nursing home admission in Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a register\u2010based drug utilization study, describing patterns of commonly used medications with sedative effects leading up to and after nursing home admission using data from 94 Danish nursing homes between 2015 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 5179 residents (median age 84\u2009years, 63% female) and described monthly incidence and total use of benzodiazepines (BZDs), Z drugs, mirtazapine\/mianserin, quetiapine, promethazine, and melatonin. The proportion of unique users of sedating medications was similar before and after admission (42% before vs. 40% after) despite an increase in total use after admission. The overall incidence of sedating medications peaked in the 6\u2009months before and 6\u2009months after admission (peaking at 4.6 per 100 person\u2010months 1\u2009month after admission). The most commonly initiated medications were mirtazapine\/mianserin, followed by BZDs and Z drugs. Total use of sedating medications increased leading up to admission (peaking at 1001 defined daily doses per 100 residents per month 1\u2009month after admission) and decreased gradually after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sedative medication initiation increases sharply leading up to admission in Danish nursing homes. Mirtazapine\/mianserin is a commonly used agent in nursing homes, despite limited evidence on benefits and harms. Efforts to promote rational use of these medications in nursing homes remain warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5341","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T08:30:44Z","timestamp":1628757044000},"page":"1560-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of sedating medications around nursing home admission in Denmark"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"first","affiliation":[{"name":"Clinical Pharmacology and Pharmacy, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Odense Deprescribing Initiative (ODIN)  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Lundby","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Pharmacy, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Odense Deprescribing Initiative (ODIN)  Odense Denmark"},{"name":"Research Unit of General Practice, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Ejg","family":"Jarb\u00f8l","sequence":"additional","affiliation":[{"name":"Research Unit of General Practice, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Post","family":"Larsen","sequence":"additional","affiliation":[{"name":"TYPE2DIALOG  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina Clauber","family":"Hoppe","sequence":"additional","affiliation":[{"name":"TYPE2DIALOG  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"TYPE2DIALOG  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Thompson","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Funen Odense University Hospital  Odense Denmark"},{"name":"Odense Deprescribing Initiative (ODIN)  Odense Denmark"},{"name":"Research Unit of General Practice, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13099"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2017.09.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2175"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2019.03.180335"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0380-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.357"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_9_9_1","volume-title":"Ten Things Physicians and Patients Should Question. 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