{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:49:15Z","timestamp":1747151355456,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H06392"],"award-info":[{"award-number":["JP18H06392"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Smoking is an important public health issue. Although measures to support smoking cessation have been implemented worldwide, smokers often fail to quit smoking after receiving pharmacotherapies for nicotine dependence. The present study evaluated the cost\u2010effectiveness of varenicline for smoking cessation compared with no pharmacotherapy using actual paid medical cost data in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of 3657 subjects who had quit smoking with varenicline or no pharmacotherapy. We extracted health examination and medical claim data from a health insurer database for the period 2012\u20132015. We calculated the incremental cost\u2010effective ratio (ICER) of varenicline using actual paid medical costs for nicotine dependence and the number needed to treat to maintain smoking cessation compared with no pharmacotherapy, considering sex, age, income, and occupation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1\u2010 and 2\u2010year smoking cessation maintenance rates were 69.7% and 62.4%, respectively. We found that 8.8% of subjects who quit smoking used varenicline for nicotine dependence and the cost per person was Japanese Yen (JPY) 52\u2009177 (U.S. dollars [USD] 474; USD 1\u00a0=\u00a0JPY 110). The ICER of varenicline was dominant when comparing 2\u2010year cessation with 1\u2010year cessation. Male, age &lt;40\u2009years, low income, and manufacturing workers were the most cost\u2010effective variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cost\u2010effective variables of varenicline in the real world were investigated. The results of this study strengthen the evidence regarding which type of people should be targeted for measures to support smoking cessation using varenicline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5359","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T15:15:44Z","timestamp":1631805344000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010effectiveness analysis of treatment with varenicline for nicotine dependence compared with smoking cessation without pharmacotherapy in the real world"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-6533","authenticated-orcid":false,"given":"Takako","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Faculty of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Health Care Administration and Management, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Babazono","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Jamal","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Health Administration Program, Department of International Business and Management Universiti Teknologi MARA, Selangor Campus  Shah Alam Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.WHO Global Report on Trends in Prevalence of Tobacco Smoking 2000\u20132025 2nd ed..WHO;2018."},{"key":"e_1_2_10_3_1","unstructured":"Ministry of Health Labour and Welfare.Ministry of Health Labour and Welfare;2019.https:\/\/www.mhlw.go.jp\/. Accessed August 28 2019."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14020202"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200927030-00007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-015-0204-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200826060-00004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckp075"},{"volume-title":"Report Nr 10\u20132010","year":"2010","author":"Hagen G","key":"e_1_2_10_9_1"},{"key":"e_1_2_10_10_1","unstructured":"Ministry of Health Labour and Welfare.Survey report of the effect of the medical treatment for nicotine dependence;2017."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14621"},{"key":"e_1_2_10_12_1","unstructured":"Japan Health Insurance Association; 2019.http:\/\/www.kyoukaikenpo.or.jp\/. 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