{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:00:25Z","timestamp":1768006825748,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Our objective was to calculate the positive predictive value (PPV) of the ICD\u20109 diagnosis code for angioedema when physicians adjudicate the events by electronic health record review. Our secondary objective was to evaluate the inter\u2010rater reliability of physician adjudication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the Cardiovascular Research Network previously diagnosed with heart failure who were started on angiotensin\u2010converting enzyme inhibitors (ACEI) during the study period (July 1, 2006 through September 30, 2015) were included. A team of two physicians per participating site adjudicated possible events using electronic health records for all patients coded for angioedema for a total of five sites. The PPV was calculated as the number of physician\u2010adjudicated cases divided by all cases with the diagnosis code of angioedema (ICD\u20109\u2010CM code 995.1) meeting the inclusion criteria. The inter\u2010rater reliability of physician teams, or kappa statistic, was also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 38\u2009061 adults with heart failure initiating ACEI in the study (21\u2009489 patient\u2010years). Of 114 coded events that were adjudicated by physicians, 98 angioedema events were confirmed for a PPV of 86% (95% CI: 80%, 92%). The kappa statistic based on physician inter\u2010rater reliability was 0.65 (95% CI: 0.47, 0.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ICD\u20109 diagnosis code of 995.1 (angioneurotic edema, not elsewhere classified) is highly predictive of angioedema in adults with heart failure exposed to ACEI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5361","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T23:46:31Z","timestamp":1632527191000},"page":"1630-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physician adjudication of angioedema diagnosis codes in a population of patients with heart failure prescribed angiotensin\u2010converting enzyme inhibitor therapy"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-3752","authenticated-orcid":false,"given":"Elizabeth T.","family":"Mansi","sequence":"first","affiliation":[{"name":"School of Public Health University of Washington  Seattle Washington USA"},{"name":"Center for Health Research, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Center for Health Research, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah L.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Sum","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Los Angeles Medical Center, Kaiser Permanente Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert Yuh\u2010Jer","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Los Angeles Medical Center, Kaiser Permanente Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Budzynska","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Markin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie H.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Health Research, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Center for Health Research, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany Q.","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaejin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Roblin","sequence":"additional","affiliation":[{"name":"Mid\u2010Atlantic Permanente Research Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E.","family":"Cassidy\u2010Bushrow","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Kuntz","sequence":"additional","affiliation":[{"name":"Center for Health Research, Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond G.","family":"Schlienger","sequence":"additional","affiliation":[{"name":"Quantitative Safety and Epidemiology, Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Behr","sequence":"additional","affiliation":[{"name":"Quantitative Safety and Epidemiology, Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-6462","authenticated-orcid":false,"given":"David 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