{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T16:15:15Z","timestamp":1746116115480},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015756","name":"Cilag","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Long\u2010term antipsychotic treatment is key to a positive clinical outcome in schizophrenia. Recent guidelines recommend the prescription of long\u2010acting antipsychotic formulations (LAIs) as early as the first episode in patients with schizophrenia. The OPTIMUS study evaluated real\u2010world use of a new three\u2010monthly paliperidone palmitate formulation (PP3M) in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this observational cross\u2010sectional study, all French psychiatrists were invited to enrol patients who had initiated PP3M in the previous 4\u2009months. Snapshot data were collected at a routine consultation, without any modification of clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This population of 350 patients with schizophrenia started on PP3M predominantly included single men, living independently with a diagnosis of schizophrenia for a median of 9.3\u2009years. Demographic characteristics were broadly comparable to those reported in other studies on LAIs. Investigators cited treatment simplification (96.9%) and patient comfort (93.3%) as the most common reasons for switching to PP3M; enhancing adherence was mentioned less often (61.1%) with most patients previously considered as adherent, and a majority of them expressing a positive attitude to their treatment. One\u2010third of patients accepted the psychiatrist's proposal to initiate PP3M treatment without any discussion, and relatives were involved in the therapeutic decision\u2010making process in only 23.7% of cases. After initiation, few changes were seen in professional follow\u2010up frequency or concomitant pharmacological and non\u2010pharmacological treatment modalities except for a decrease in antipsychotic polytherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PP3M is mostly prescribed in adherent patients with fairly stable schizophrenia, and the longer dosing interval does not substantially affect patient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5397","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T08:35:02Z","timestamp":1639298102000},"page":"334-342","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initiation of quarterly palmitate paliperidone in French clinical practice: Results from the observational, cross\u2010sectional OPTIMUS study"],"prefix":"10.1002","volume":"31","author":[{"given":"Charlotte","family":"Gary","sequence":"first","affiliation":[{"name":"Medical Affairs Department Janssen  Issy\u2010les\u2010Moulineaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"D\u00e9al","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Janssen  Issy\u2010les\u2010Moulineaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Boursicot\u2010Beuzelin","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Janssen  Issy\u2010les\u2010Moulineaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Falissard","sequence":"additional","affiliation":[{"name":"Paris\u2010Descartes University, Maison de Solenn  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Yves","family":"Giordana","sequence":"additional","affiliation":[{"name":"Association Hospitali\u00e8re Sainte\u2010Marie Centre Hospitalier Sainte\u2010Marie  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Fakra","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Saint\u2010\u00c9tienne, H\u00f4pital de la Charit\u00e9  Saint\u2010\u00c9tienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Samalin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHU Clermont\u2010Ferrand University of Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal (UMR 6602)  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Bouju","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Janssen  Issy\u2010les\u2010Moulineaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","first-page":"638","article-title":"Schizophrenia: overview and treatment options","volume":"39","author":"Patel KR","year":"2014","journal-title":"Peer\u2010Rev J Formul Manag"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.28"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18091036r"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.05.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i5.74"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S96214"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38881.382755.2F"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.12.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00101"},{"key":"e_1_2_10_11_1","first-page":"845","article-title":"Dosing and switching strategies for paliperidone palmitate: based on population pharmacokinetic modelling and clinical trial data","volume":"25","author":"Samtani MN","year":"2011","journal-title":"CNS Drugs"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1085849"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m11308"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-7006(13)70121-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0241"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000190"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2011.13.2\/ccorrell"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320926347"},{"issue":"7","key":"e_1_2_10_19_1","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner J","year":"2007","journal-title":"Psychiatry"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.09.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870449908407311"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173267"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.10.022"},{"key":"e_1_2_10_24_1","first-page":"26","article-title":"Comparison of Paliperidone palmitate and risperidone long\u2010acting injection in schizophrenic patients: results from a multicenter retrospective cohort study in France","volume":"38","author":"Limosin F","year":"2017","journal-title":"J Clin Psychopharmacol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112560"},{"issue":"1","key":"e_1_2_10_26_1","first-page":"38","article-title":"Prevalence of cigarette smoking in schizophrenic patients compared to other hospital admitted psychiatric patients","volume":"1","author":"Ziaaddini H","year":"2009","journal-title":"Addict Heal"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.06.026"},{"issue":"2","key":"e_1_2_10_28_1","first-page":"115","article-title":"Addiction and schizophrenia","volume":"15","author":"Batel P","year":"2000","journal-title":"Eur Psych J Assoc Eur Psych"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.1\/bwinklbaur"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp016"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1039856218789770"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2009.60.8.1107"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.9.1219"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:34:51Z","timestamp":1692815691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/pds.5397"],"URL":"https:\/\/doi.org\/10.1002\/pds.5397","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"2021-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}