{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:32:53Z","timestamp":1772148773592,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Large electronic medical record (EMR) databases can facilitate epidemiology research into uncommon diseases such as interstitial lung disease (ILD). Given the rarity and diagnostic difficulty of ILD, the validity of the coding in EMR requires clarification. We aimed to assess the validity of International Classification of Diseases, 9th Revision (ICD\u20109) code algorithms for identifying ILD in the territory\u2010wide electronic medical health record system of Clinical Data Analysis and Reporting System (CDARS) in Hong Kong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients who visited the Queen Mary Hospital in 2005\u20132018 with ILD were identified using the following ICD\u20109 codes: post\u2010inflammatory pulmonary fibrosis (PPF; ICD\u20109: 515), idiopathic fibrosing alveolitis (IFA; ICD\u20109: 516.3), connective tissue disease\u2010associated interstitial lung disease (CTD\u2010ILD; ICD\u20109: 517.2, 517.8, 714.81), sarcoidosis (ICD\u20109: 135) and extrinsic allergic alveolitis (EAA; ICD\u20109: 495). A random selection was conducted in cases with diagnostic code of PPF and IFA, where a relative higher case number was identified. All the cases of CTD\u2010ILD, sarcoidosis and EAA were included in validation for relatively small case number.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and sixty nine cases were validated using medical record review by a respiratory specialist. The overall positive predictive value (PPV) was 79% (95% CI, 74%\u201384%). In subgroup analysis, true positive case numbers of PPF, IFA, CTD\u2010ILD, sarcoidosis and EAA were 74\/100 (74%), 95\/100 (95%), 11\/15 (73%), 27\/32 (84%) and 6\/22 (27%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This was the first ICD\u20109 coding validation for ILD in Hong Kong CDARS. Our study demonstrated that using ICD\u20109 algorithms 515, 516.3, 517.2, 517.8, 714.81 and 135 enhanced identifications of ILDs with PPV that was reliable to support utility of CDARS database for further clinical research on ILDs. The validity is particularly high with 516.3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5421","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T08:09:12Z","timestamp":1645862952000},"page":"519-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Validation of diagnostic coding for interstitial lung diseases in an electronic health record system in <scp>Hong Kong<\/scp>"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7570-5740","authenticated-orcid":false,"given":"Yisha","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacy The University of Hong Kong  Pokfulam Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hubbard","sequence":"additional","affiliation":[{"name":"School of Medicine University of Nottingham  Nottingham 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