{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:47:51Z","timestamp":1787510871813,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006425","name":"NFL Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid COVID\u201019 testing platforms can identify infected individuals at the point of care (POC), allowing immediate isolation of infected individuals and reducing the risk of transmission. While lab\u2010based nucleic acid amplification testing (NAAT) is often considered the gold standard to detect SARS\u2010CoV\u20102 in the community, results typically take 2\u20137\u2009days to return, rendering POC testing a critical diagnostic tool for infection control. The National Football League (NFL) and NFL Players Association deployed a new POC testing strategy using a newly available reverse transcriptase polymerase chain reaction (RT\u2010PCR) rapid test during the 2020 season, and evaluated diagnostic effectiveness compared to other available devices using real\u2010world population surveillance data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RT\u2010PCR POC test results were compared to NAAT results from same\u2010day samples by calculation of positive and negative concordance. Sensitivity analyses were performed for three subgroups: (1) individuals symptomatic at time of positive test; (2) individuals tested during the pilot phase of rollout; and (3) individuals tested daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4989 same\u2010day POC\/NAAT pairs, 4957 (99.4%) were concordant, with 93.1% positive concordance and 99.6% negative concordance. Based on adjudicated case status, the false negative rate was 0.2% and false positive rate was 2.9%. In 43 instances, the immediate turnaround of results by POC allowed isolation of infected individuals 1 day sooner than lab\u2010based testing. Positive\/negative concordance in sensitivity analyses were relatively stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RT\u2010PCR POC testing provided timely results that were highly concordant with lab\u2010based NAAT in population surveillance. Expanded use of effective RT\u2010PCR POC can enable rapid isolation of infected individuals and reduce COVID\u201019 infection in the community.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.5424","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T06:45:30Z","timestamp":1646030730000},"page":"511-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness and use of\n                    <scp>reverse transcriptase polymerase chain reaction<\/scp>\n                    point of care testing in a\n                    <scp>large\u2010scale COVID<\/scp>\n                    \u201019 surveillance system"],"prefix":"10.1002","volume":"31","author":[{"given":"Christina D.","family":"Mack","sequence":"first","affiliation":[{"name":"Real World Solutions IQVIA  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin 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Pathology University of Maryland Medical System  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Eichner","sequence":"additional","affiliation":[{"name":"Sports Medicine Research and Testing Laboratory University Research Park  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thom","family":"Mayer","sequence":"additional","affiliation":[{"name":"School of Medicine Duke University  Durham North Carolina USA"},{"name":"National Football League Players Association  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Sills","sequence":"additional","affiliation":[{"name":"Player Health and Safety Department National Football League  New York City New York 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