{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:36:50Z","timestamp":1788367010810,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["L30AR076081"],"award-info":[{"award-number":["L30AR076081"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR075888"],"award-info":[{"award-number":["K23AR075888"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Actinic keratoses (AK) diagnosis, billing, and pharmacy codes have not been validated among people living with human immunodeficiency virus (HIV), preventing use in epidemiologic and clinical research. We aimed to calculate the positive predictive value (PPV) of AK diagnosis codes, procedural codes for destruction of pre\u2010malignant lesions, and pharmacy codes for topical 5\u2010fluorouracil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with HIV within the Infectious Disease clinic at the Atlanta Veterans Affairs Medical Center from 1\/1\/2002 to 8\/5\/2017 were eligible. Patients were included if they had any of the following: encounters with a diagnosis for AK (International Classification of Diseases [ICD]\u20109: 702.0; ICD\u201010: L57.0), procedural codes for destruction of premalignant lesions (Current Procedural Terminology [CPT]: 17000, 17003, and 17004), and prescriptions for topical 5\u2010fluorouracil. PPV and binomial 95% confidence intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PPV was 91.9% (89.1\u201394.7) for 369 encounters with an AK diagnosis. For procedural codes, PPV was 52.6% (48.1\u201357.2) for 454 encounters with destruction of 1 pre\u2010malignant lesion, 63.7% (58.4\u201368.9) for 322 encounters with destruction of 2\u201314 lesions, and 57.7% (38.7\u201376.7) for 26 encounters with destruction of 15+ lesions. PPV was 72.9% (63.5\u201382.4) for 85 encounters with a prescription of topical 5\u2010fluorouracil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AK diagnosis codes are appropriate to use in epidemiologic and health policy research among people living with HIV and may be more reliable than destruction of pre\u2010malignant lesion CPT codes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5430","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T06:43:31Z","timestamp":1647499411000},"page":"998-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of actinic keratosis diagnosis and treatment codes among veterans living with <scp>HIV<\/scp>"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-3776","authenticated-orcid":false,"given":"Krittin J.","family":"Supapannachart","sequence":"first","affiliation":[{"name":"Department of Dermatology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-5762","authenticated-orcid":false,"given":"Chase W.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-4732","authenticated-orcid":false,"given":"Sokol","family":"Tushe","sequence":"additional","affiliation":[{"name":"Department of Information Systems and Operations Management Emory University Goizueta Business School  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-3975","authenticated-orcid":false,"given":"Jodie L.","family":"Guest","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-7380","authenticated-orcid":false,"given":"Suephy C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Durham Veterans Affairs Medical Center  Durham North Carolina USA"},{"name":"Department of Dermatology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-4936","authenticated-orcid":false,"given":"Howa","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Clinical Resource Hub Veterans Integrated Service Network VISN 7  Decatur Georgia 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