{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:38:16Z","timestamp":1773506296287,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["SAF\u201094814"],"award-info":[{"award-number":["SAF\u201094814"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the impact of restrictions on access to long acting oxycodone on prescription opioid use and opioid\u2010related harms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Administrative health data from Ontario, Canada was used to measure differences in opioids dispensed and emergency department (ED) visits for opioid\u2010related overdose, poisoning, or substance use following provincial restrictions on access to publicly insured OxyContin (February 29, 2012) and OxyNeo (February 28, 2013). This study focused on the cohort of provincial drug insurance eligible people (people 65+ and select low\u2010income populations) who were dispensed oxycodone prior to the restrictions. Difference\u2010in\u2010differences models with a propensity score matched comparison group of people who were dispensed non\u2010oxycodone opioids were used to estimate the main effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 6\u2009months following the delisting of OxyContin, milligrams of morphine equivalents (MMEs) per person per week for all opioids fell by an average of 7.5% in people dispensed oxycodone relative to the comparison group, and an average of 13.8% in chronic recipients of oxycodone. In the 6\u2009months following the restrictions on OxyNeo, MMEs per person per week fell by an average of 3.1% in all people dispensed oxycodone, and 25.2% in chronic oxycodone recipients. The decline in oxycodone dispensing among chronic oxycodone recipients corresponded with an increase in dispensing of other opioid formulations, particularly hydromorphone and fentanyl. No important differences were observed for ED visits related to opioid poisoning, overdose, or substance use disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Province\u2010wide restrictions on access to long acting oxycodone had an impact on quantities of all opioids dispensed to chronic recipients of oxycodone, but small impacts on the full population of people dispensed oxycodone; the decline in use was partially offset by increases in use of other publicly\u2010funded opioid formulations. This study suggests that policies limiting access to specific prescription opioids led to overall reductions in publicly funded prescription opioid use, particularly in chronic oxycodone recipients, without immediate evidence of changes in opioid\u2010related ED visits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5442","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T07:20:30Z","timestamp":1650957630000},"page":"769-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the population\u2010level effects of oxycodone restrictions on prescription opioid utilization in Ontario"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-5829","authenticated-orcid":false,"given":"David","family":"Rudoler","sequence":"first","affiliation":[{"name":"Ontario Shores Centre for Mental Health Sciences  Whitby Ontario Canada"},{"name":"Faculty of Health Sciences Ontario Tech University  Oshawa Ontario Canada"},{"name":"ICES  Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kurdyak","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-1965","authenticated-orcid":false,"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Ontario Canada"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto  Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjie","family":"Huang","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Applied Research in Mental Health and Addiction (CARMHA), Faculty of Health Sciences Simon Fraser University  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Littleford","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ontario Tech University  Oshawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabiha","family":"Paracha","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ontario Tech University  Oshawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2186-4030","authenticated-orcid":false,"given":"Benedikt","family":"Fischer","sequence":"additional","affiliation":[{"name":"Centre for Applied Research in Mental Health and Addiction (CARMHA), Faculty of Health Sciences Simon Fraser University  Vancouver British Columbia Canada"},{"name":"Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry Federal University of S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40545\u2010020\u201000271\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.38.6.02"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160356"},{"key":"e_1_2_9_5_1","volume-title":"Prescribed Drug Spending in Canada, 2020: A Focus on Public Drug Programs","author":"Canadian Institute for Health Information","year":"2020"},{"key":"e_1_2_9_6_1","volume-title":"9 Million Prescriptions: What we Know about the Growing Use of Prescription Opioids in Ontario","author":"Health Quality Ontario","year":"2017"},{"key":"e_1_2_9_7_1","volume-title":"Opioid Use and Related Adverse Events in Ontario","author":"Ontario Drug Policy Research Network","year":"2016"},{"key":"e_1_2_9_8_1","unstructured":"Expert Working Group on Narcotic Addiction.The Way Forward: Stewardship for Prescription Narcotics in Ontario. 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