{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:50:38Z","timestamp":1792799438104,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In tuberculosis (TB) treatment, adverse drug reactions (ADRs) can interrupt treatment and decrease the quality of life (QoL). We aimed to prospectively investigate the incidence of ADRs to first\u2010line anti\u2010TB drugs and related outcomes and QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with TB who had been treated with first\u2010line anti\u2010TB drugs in five Korean hospitals were enrolled. ADR questionnaire surveys and blood tests were performed four times serially, and QoL was assessed on the fourth TB treatment week (\u00b12\u2009weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 410 enrolled patients with TB (males, 62%; mean age, 52.1\u2009\u00b1\u200918.1\u2009years [those aged \u226565\u2009years, 26.6%]), 67.8% experienced any ADRs (\u2265 grade 2) to TB drugs. The most common ADR was fatigue (53.2%), followed by itching (42.7%) and anorexia (41.7%). Older adult patients experienced relatively more ADRs, including anorexia, dyspepsia, rash, dizziness, anemia, abnormal hepatic\/renal function tests, and increased uric acid levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Treatment regimens changed for 9.5% of patients owing to ADRs to anti\u2010TB drugs. Patients with any ADRs and older adult patients had significantly lower QoL than their counterparts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Old age (odds ratio [OR], 1.02) and being male (OR 2.65) were independently associated with ADRs, whereas active smoking (OR 4.73) and a relatively long treatment phase (OR 5.13) were independently associated with hepatotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADRs to first\u2010line anti\u2010TB drugs were common and related to relatively low QoL, especially among older adults. Although 9.5% of patients had ADR\u2010related regimen changes, most patients with ADRs completed treatments successfully.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.5513","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T01:05:33Z","timestamp":1659315933000},"page":"1153-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Incidence and outcomes of adverse drug reactions to first\u2010line anti\u2010tuberculosis drugs and their effects on the quality of life: A multicenter prospective cohort study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-0653","authenticated-orcid":false,"given":"Hayoung","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital Seoul South Korea"},{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-0828","authenticated-orcid":false,"given":"Hang A.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-9476","authenticated-orcid":false,"given":"In Gyu","family":"Hyun","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-5149","authenticated-orcid":false,"given":"Joo\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Sacred Heart Hospital Anyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-5211","authenticated-orcid":false,"given":"Yong\u2010Il","family":"Hwang","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Sacred Heart Hospital Anyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-5780","authenticated-orcid":false,"given":"Seung Hun","family":"Jang","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Sacred Heart Hospital Anyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-4947","authenticated-orcid":false,"given":"Yun Su","family":"Sim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital Seoul South Korea"},{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-2454","authenticated-orcid":false,"given":"Tae Rim","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital Seoul South Korea"},{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-6590","authenticated-orcid":false,"given":"Yousang","family":"Ko","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Kangdong Sacred Heart Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-742X","authenticated-orcid":false,"given":"Ga Young","family":"Ban","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Kangdong Sacred Heart Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-7706","authenticated-orcid":false,"given":"Ji Young","family":"Hong","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-4993","authenticated-orcid":false,"given":"Chang Youl","family":"Lee","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-1653","authenticated-orcid":false,"given":"Myung Goo","family":"Lee","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0599-875X","authenticated-orcid":false,"given":"Jeong\u2010Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Lung Research Institute, Hallym University College of Medicine Chuncheon South Korea"},{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2020;2020."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2021.367"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000462"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"144","article-title":"Incidence and risk factors of major toxicity associated to first\u2010line antituberculosis drugs for latent and active tuberculosis during a period of 10\u2009years","volume":"21","author":"Castro AT","year":"2006","journal-title":"Rev Port Pneumol"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027321"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09102026"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027610"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs046"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-019-01324-3"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(03)OA08"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132008001200010"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw566"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.104"},{"key":"e_1_2_12_15_1","volume-title":"Korean Guidelines for Tuberculosis","author":"Joint Committee for the Revision of Korean Guidelines for Tuberculosis","year":"2020"},{"key":"e_1_2_12_16_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) v5.0","author":"National Cancer Institute","year":"2017"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.09.004"},{"key":"e_1_2_12_18_1","volume-title":"WHO\u2010BREF: Introduction, Administration, Scoring and Generic Version of Assessment","author":"World Health Organization","year":"1996"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/412893"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065037"},{"issue":"4","key":"e_1_2_12_21_1","first-page":"251","article-title":"Adverse drug reactions observed during DOTS","volume":"36","author":"Dhingra VK","year":"2004","journal-title":"J Commun Dis"},{"issue":"3","key":"e_1_2_12_22_1","first-page":"134","article-title":"Evaluation of anti\u2010tuberculosis induced adverse reactions in hospitalized patients","volume":"4","author":"Gholami K","year":"2006","journal-title":"Pharm Pract (Granada)"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132010000200012"},{"issue":"2","key":"e_1_2_12_24_1","first-page":"143","article-title":"Two years review of cutaneous adverse drug reaction from first line anti\u2010tuberculous drugs","volume":"62","author":"Tan WC","year":"2007","journal-title":"Med J Malaysia"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/322671"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2015.10.005"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.2.465"},{"issue":"11","key":"e_1_2_12_28_1","first-page":"995","article-title":"Risk factors for hepatotoxicity associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection: experience from three public health tuberculosis clinics","volume":"6","author":"Lee AM","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-8-200210150-00007"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236109"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.01.011"},{"issue":"5","key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.21315\/mjms2018.25.5.10","article-title":"Evaluation of adverse reactions induced by anti\u2010tuberculosis drugs in hospital Pulau Pinang","volume":"25","author":"Fei CM","year":"2018","journal-title":"Malays J Med Sci"},{"issue":"1","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.4103\/0019-509X.147472","article-title":"Levels and trends of smokeless tobacco use among youth in countries of the World Health Organization South\u2010East Asia region","volume":"51","author":"Sinha DN","year":"2014","journal-title":"Indian J Cancer"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200802-355OC"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08856-6"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00251-2021"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.18.0047"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17010210"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:14:56Z","timestamp":1727676896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/pds.5513"],"URL":"https:\/\/doi.org\/10.1002\/pds.5513","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"value":"1053-8569","type":"print"},{"value":"1099-1557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}