{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:49:32Z","timestamp":1747151372729,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Infection is a major complication following joint replacement (JR) surgery. However, little data exist regarding antibiotic utilisation following primary JR and how use changes with subsequent revision surgery. This study aimed to examine variation in antibiotic utilisation rates before and after hip replacement surgery in those revised for infection, revised for other reasons and those without revision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort analysis used linked data from the Australian Orthopaedic Association National Joint Replacement Registry and Australian Government Pharmaceutical Benefits Scheme. Patients were included if undergoing total hip replacement (THR) for osteoarthritis in private hospitals between 2002 and 2017. Three groups were examined: primary THR with no subsequent revision (<jats:italic>n<\/jats:italic>\u00a0=\u00a0102\u2009577), primary THR with a subsequent revision for reasons other than periprosthetic joint infection (PJI) (<jats:italic>n<\/jats:italic>\u00a0=\u00a03156) and primary THR with a subsequent revision for PJI (<jats:italic>n<\/jats:italic>\u00a0=\u00a0520). Monthly antibiotic utilisation rates and prevalence rate ratios (PRRs) with 95% confidence intervals (CIs) were calculated in the 2\u2009years pre\u2010 and post\u2010THR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to primary THR antibiotic utilisation was 9%\u201310%. After primary THR, antibiotic utilisation rates were higher among patients revised for PJI (PRR 1.69, 95% CI 1.60\u20131.79) compared to non\u2010revised patients, while the utilisation rate was lower in patients revised for reasons other than infection (PRR 0.96, 95% CI 0.93\u20130.98). For those revised for infection, antibiotic utilisation post\u2010revision surgery was two times higher than those revised for other reasons (PRR 2.16, 95% CI 2.08\u20132.23). Utilisation of injectable antibiotics including, vancomycin, flucloxacillin and cephazolin was higher in those revised for PJI patients 0\u20132\u2009weeks following surgery but not in those revised for other reasons compared to the non\u2010revised group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ongoing antibiotic utilisation after primary surgery may be an early signal of problems with the THR and should be a prompt for primary care physicians to refer patients to specialists for further appropriate investigations and management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5522","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T08:04:23Z","timestamp":1660550663000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibiotic utilisation in primary and revision total hip replacement patients: A registry linkage cohort study of 106\u2009253 patients using the Australian Orthopaedic Association National Joint Replacement Registry"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-2040","authenticated-orcid":false,"given":"Richard N.","family":"de Steiger","sequence":"first","affiliation":[{"name":"Department of Surgery, Epworth Healthcare University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian Orthopaedic Association National Joint Replacement Registry South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-8910","authenticated-orcid":false,"given":"Nicole L.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Services University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-1476","authenticated-orcid":false,"given":"Aarti","family":"Gulyani","sequence":"additional","affiliation":[{"name":"Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Services University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3532-7233","authenticated-orcid":false,"given":"Katherine M.","family":"Duszynski","sequence":"additional","affiliation":[{"name":"Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Services University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-2665","authenticated-orcid":false,"given":"Maria C.","family":"Inacio","sequence":"additional","affiliation":[{"name":"Registry of Senior Australians South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-319X","authenticated-orcid":false,"given":"Stephen E.","family":"Graves","sequence":"additional","affiliation":[{"name":"Australian Orthopaedic Association National Joint Replacement Registry South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-5694","authenticated-orcid":false,"given":"Paul N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Australian National University Medical School Australian National University  Canberra Australian Capital Territory Australia"},{"name":"Department of Orthopaedic Surgery Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"For the Improving Joint Replacement Outcomes in Australia using National Data Linkage Study Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5289-6"},{"issue":"7","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"e014056","DOI":"10.1136\/bmjopen-2016-014056","article-title":"Description of the rates, trends and surgical burden associated with revision for prosthetic joint infection following primary and revision knee replacements in England and Wales: an analysis of the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man","volume":"7","author":"Lenguerrand E","year":"2017","journal-title":"BMJ Open"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2264-7"},{"volume-title":"Hip, Knee & Shoulder Arthroplasty: 2021 Annual Report","year":"2021","author":"Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR)","key":"e_1_2_10_5_1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470310018135"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.007117"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30345-1"},{"key":"e_1_2_10_9_1","unstructured":"Australian Government Department of Health.Pharmaceutical Benefits Scheme: Browse by Body System (Group J \u2010 Antiinfectives for Systemic Use) The Pharmaceutical Benefits Scheme 2019.http:\/\/www.pbs.gov.au\/browse\/body-system?depth=1&codes=j#j."},{"key":"e_1_2_10_10_1","unstructured":"World Health Organization (WHO).Antibiotic resistance. WHO. Updated July 31 2020 2020.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antibiotic-resistance"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1616-8"},{"key":"e_1_2_10_12_1","unstructured":"Australian Government Department of Health.About the PBS. The Pharmaceutical Benefits Scheme. Updated January 01 2022 2021.http:\/\/www.pbs.gov.au\/info\/about-the-pbs#Who_is_eligible_for_a_concession."},{"volume-title":"Analysis of State & Territory Health Data: All Arthroplasty Supplementary Report in Hip, Knee & Shoulder Arthroplasty: 2021 Annual Report","year":"2021","author":"Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR)","key":"e_1_2_10_13_1"},{"key":"e_1_2_10_14_1","article-title":"Oral antibiotic prescribing in the community: then and now","volume":"96","author":"Ford D","year":"2015","journal-title":"Aust J Pharm"},{"key":"e_1_2_10_15_1","unstructured":"Antibiotic Expert Group.Therapeutic guidelines: antibiotic. Therapeutic Guidelines Limited. Updates 2019 2020.https:\/\/tgldcdp.tg.org.au\/guideLine?guidelinePage=Antibiotic&frompage=etgcomplete"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01766-13"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201012000-00007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B3.36705"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1011983"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.35.BJO-2022-0011.R1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.14325"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpubeco.2018.08.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2010.100044"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-8-78"},{"issue":"4","key":"e_1_2_10_25_1","first-page":"158","article-title":"Cherry\u2010picking: if, why and how much? Audit of co\u2010morbidities in patients undergoing primary total hip and total knee replacements at independent sector treatment centres compared with district general hospitals","volume":"94","author":"Fagg J","year":"2012","journal-title":"Orthop Proc"}],"container-title":["Pharmacoepidemiology and Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pds.5522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pds.5522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:02:54Z","timestamp":1692576174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pds.5522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/pds.5522"],"URL":"https:\/\/doi.org\/10.1002\/pds.5522","archive":["Portico"],"relation":{},"ISSN":["1053-8569","1099-1557"],"issn-type":[{"type":"print","value":"1053-8569"},{"type":"electronic","value":"1099-1557"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2021-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}