{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:33:24Z","timestamp":1784349204819,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nitrosatable drugs can be synthesized to N\u2010nitroso compounds in human stomach. In a pregnant woman, N\u2010nitroso compounds can be translocated to the fetus through the placenta. Maternal exposure of nitrosatable compounds during pregnancy has been associated with childhood brain tumors and leukemia. However, few studies have investigated an association between nitrosatable drug exposure during pregnancy and childhood cancer. We examined if maternal prescriptions of nitrosatable drugs received during pregnancy are associated with childhood cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A matched case\u2010control study was conducted using Danish nationwide registry data from 1995 to 2016. Each childhood cancer case was matched with twenty\u2010five controls. Maternal exposure of nitrosatable drugs during pregnancy was identified from the Danish National Prescription Register. A multivariable conditional logistic regression model was used to estimate adjusted odds ratios (adj.OR) with 95% confidence intervals (CI) for each childhood cancer type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal prescriptions of nitrosatable drugs positively associate with central nervous system tumors (adj.OR = 1.25; 95% CI = 1.04\u20131.51) and neuroblastoma (adj.OR = 1.96; 95% CI = 1.34\u20132.85) in offspring. We also observed a positive association between perinatal exposure of nitrosatable drugs and acute lymphoblastic leukemia (adj.OR = 1.31; 95% CI = 1.07\u20131.59), however, it appeared to be due to confounding by indication, i.e., maternal infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nitrosatable drug use during pregnancy potentially increased risk of central nervous system tumors and neuroblastoma. While a positive association between maternal prescriptions of nitrosatable drugs and acute lymphoblastic leukemia should be interpreted cautiously because of confounding by indication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5557","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T10:28:23Z","timestamp":1666866503000},"page":"496-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exposure to nitrosatable drugs during pregnancy and childhood cancer: A matched case\u2013control study in Denmark, 1996\u20132016"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-2680","authenticated-orcid":false,"given":"Anupong","family":"Sirirungreung","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnni","family":"Hansen","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"},{"name":"College of Health and Public Service University of North Texas  Denton Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Relevance of N\u2010nitroso compounds to human cancer: exposures and mechanisms. 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