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First, the drugs suspected to induce DIN or DIA were selected. The associations between suspected drugs and DIN or DIA were evaluated by a retrospective cohort study using unconditional logistic regression analysis and multiple linear regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve suspected drugs (vancomycin, meropenem, voriconazole, acyclovir, ganciclovir, fluconazole, oseltamivir, linezolid, compound borax solution, palonosetron, polyene phosphatidylcholine, and sulfamethoxazole) were associated with DIN, and six suspected drugs (vancomycin, voriconazole, acyclovir, ganciclovir, fluconazole, and oseltamivir) were associated with DIA. The multivariate linear regression model revealed that nine drugs (vancomycin, meropenem, voriconazole, ganciclovir, fluconazole, oseltamivir, compound borax solution, palonosetron, and polyene phosphatidylcholine) and four drugs (vancomycin, voriconazole, ganciclovir, and fluconazole) were found to be associated with DIN and DIA, respectively. While logistic regression analysis revealed that palonosetron and ganciclovir were associated with DIN and DIA, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Palonosetron and ganciclovir were found to be correlated with drug\u2010induced granulocytopenia. The results of this study provide an early warning of drug safety signals for drug\u2010induced granulocytopenia, facilitating a quick and appropriate response for clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5559","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T11:35:26Z","timestamp":1666956926000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of drug safety signal of drug\u2010induced neutropenia and agranulocytosis in all\u2010aged patients using electronic medical records"],"prefix":"10.1002","volume":"32","author":[{"given":"Cuicui","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacy Qilu hospital of Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Qilu hospital 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