{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:34Z","timestamp":1790836774946,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Potentially inappropriate medications (PIMs) have become a major issue in improving prescribing practices and reducing the risk of adverse drug events in older people. However, very few studies have compared exposition to PIMs controlling for differences in demographic and health between nursing home residents (NHRs) and community\u2010dwelling older adults (CDOAs). This study aimed to assess the prescribing pattern of PIMs between NHRs and CDOAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study over three\u2009months in 2019 using the French Health Insurance databases. The study population included 274\u2009971 NHRs and 4\u2009893\u2009721 CDOAs aged 75\u2009years or over. The prevalence ratio (PR) between NHRs and CDOAs of 17 PIM indicators, based on the Beers and STOPP criteria lists, was assessed using multivariable robust Poisson regression adjusted for age, sex, diseases, and polypharmacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 54% of NHRs and 29% of CDOAs received at least one PIM. After adjustment, the prevalence of PIMs was 33% higher among NHRs compared to CDOAs (aPR\u00a0=\u00a01.33; 95% CI [1.33\u20131.34]). NHRs received PIMs related to benzodiazepines (aPR\u00a0=\u00a01.43; 95% CI [1.42\u20131.43]), anticholinergic drugs (aPR\u00a0=\u00a01.29; 95% CI [1.27\u20131.31]), and at least three central nervous system\u2010active drugs (aPR\u00a0=\u00a01.94; 95% CI [1.92\u20131.96]) more frequently. Prevalence of PIMs related to non\u2010steroidal anti\u2010inflammatory drugs (aPR\u00a0=\u00a00.50; 95% CI [0.48\u20130.52]) and long\u2010acting benzodiazepines (aPR\u00a0=\u00a00.84; 95% CI [0.82\u20130.85]) was lower among NHRs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The NHRs were at greater risk for PIM than CDOAs, although differences exist according to the category of PIMs. As the population is aging, it is essential to promote and evaluate interventions in NHs and the community to enhance medication optimization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5575","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T03:05:30Z","timestamp":1669345530000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potentially inappropriate medications in nursing homes and the community older adults using the French health insurance databases"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-1901","authenticated-orcid":false,"given":"Solene","family":"Drusch","sequence":"first","affiliation":[{"name":"EPI\u2010PHARE, Epidemiology of Health Products French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance  Saint\u2010Denis France"},{"name":"UVSQ, Inserm, Anti\u2010Infective Evasion and Pharmacoepidemiology University of Paris\u2010Saclay  Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien","family":"Le Tri","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE, Epidemiology of Health Products French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ankri","sequence":"additional","affiliation":[{"name":"UVSQ, Inserm, Anti\u2010Infective Evasion and Pharmacoepidemiology University of Paris\u2010Saclay  Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Michelon","sequence":"additional","affiliation":[{"name":"Pharmacy Department Sainte\u2010P\u00e9rine Hospital, AP\u2010HP, University of Paris\u2010Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Zureik","sequence":"additional","affiliation":[{"name":"EPI\u2010PHARE, Epidemiology of Health Products French National Agency for the Safety of Medicines and Health Products, and French National Health Insurance  Saint\u2010Denis France"},{"name":"UVSQ, Inserm, Anti\u2010Infective Evasion and Pharmacoepidemiology University of Paris\u2010Saclay  Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-705X","authenticated-orcid":false,"given":"Marie","family":"Herr","sequence":"additional","affiliation":[{"name":"UVSQ, Inserm, Anti\u2010Infective Evasion and Pharmacoepidemiology University of Paris\u2010Saclay  Montigny le Bretonneux France"},{"name":"Epidemiology and Public Health Department AP\u2010HP, University of Paris\u2010Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60240\u20102"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics5040085"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12596"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.10.022"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010017\u20102225\u20103"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2018.10.006"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa057"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13331"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2016.11.003"},{"key":"e_1_2_13_11_1","unstructured":"Corselli\u2010NordbladL StrandellH European Commission Statistical Office of the European Union.Ageing Europe: looking at the lives of older people in the EU: 2020 Edition. 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