{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:43:59Z","timestamp":1789454639948,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50\u2010100707"],"award-info":[{"award-number":["P50\u2010100707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01\u2010155258\u201007"],"award-info":[{"award-number":["P01\u2010155258\u201007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["857078"],"award-info":[{"award-number":["857078"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to evaluate and compare the performance of multiple myeloma (MM) selection algorithms for use in Veterans Affairs (VA) research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the VA Corporate Data Warehouse (CDW), the VA Cancer Registry (VACR), and VA pharmacy data, we randomly selected 500 patients from 01\/01\/1999 to 06\/01\/2021 who had (1) either one MM diagnostic code OR were listed in the VACR as having MM AND (2) at least one MM treatment code. A team reviewed oncology notes for each veteran to annotate details regarding MM diagnosis and initial treatment within VA. We evaluated inter\u2010annotator agreement and compared the performance of four published algorithms (two developed and validated external to VA data and two used in VA data).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 859 patients were reviewed to obtain 500 patients who were annotated as having MM and initiating MM treatment in VA. Agreement was high among annotators for all variables: MM diagnosis (98.3% agreement, Kappa\u00a0=\u00a00.93); initial treatment in VA (91.8% agreement; Kappa\u00a0=\u00a00.77); and initial treatment classification (87.6% agreement; Kappa\u00a0=\u00a00.86). VA Algorithms were more specific and had higher PPVs than non\u2010VA algorithms for both MM diagnosis and initial treatment in VA. We developed the \u201cVA Recommended Algorithm,\u201d which had the highest PPV among all algorithms in identifying patients diagnosed with MM (PPV\u00a0=\u00a00.98, 95% CI\u00a0=\u00a00.95\u20130.99) and in identifying patients who initiated their MM treatment in VA (PPV\u00a0=\u00a00.93, 95% CI\u00a0=\u00a00.90\u20130.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our VA Recommended Algorithm optimizes sensitivity and PPV for cohort selection and treatment classification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5579","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T10:46:42Z","timestamp":1669978002000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Validation of algorithms to select patients with multiple myeloma and patients initiating myeloma treatment in the national Veterans Affairs Healthcare System"],"prefix":"10.1002","volume":"32","author":[{"given":"Jennifer","family":"La","sequence":"first","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"DuMontier","sequence":"additional","affiliation":[{"name":"New England Geriatrics Research, Education and Clinical Center VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Division of Aging Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Hassan","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Edwards","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Verma","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Ferri","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts USA"},{"name":"Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuri","family":"Dharne","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Corrigan","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"Division of Aging Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan V.","family":"Do","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Brophy","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Driver","sequence":"additional","affiliation":[{"name":"New England Geriatrics Research, Education and Clinical Center VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Division of Aging Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil C.","family":"Munshi","sequence":"additional","affiliation":[{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael R.","family":"Fillmore","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)  Boston Massachusetts USA"},{"name":"VA Boston CSP Center  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010018\u20100141\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13123053"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.8033"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4711"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3883"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnu.12631"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20827"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NAQ.0000000000000118"},{"issue":"3","key":"e_1_2_12_11_1","first-page":"76","volume":"46","author":"Zullig LL","year":"2019","journal-title":"J Registry Manag"},{"key":"e_1_2_12_12_1","volume-title":"Strategies and Priorities for Information Technology at the Centers for Medicare and Medicaid Services","author":"Committee on Future Information Architectures Processes and Strategies for the Centers for Medicare and Medicaid Services","year":"2012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25603"},{"issue":"7","key":"e_1_2_12_14_1","first-page":"578","article-title":"Management of Monoclonal Gammopathy of Undetermined Significance (MGUS) and smoldering multiple myeloma (SMM)","volume":"25","author":"Kyle RA","year":"2011","journal-title":"Oncol Williston Park N"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201010\u20101822"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_12_17_1","unstructured":"Lenalidomide \u2010 NCI.Published October 5 2006. 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