{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:28:06Z","timestamp":1782368886397,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The number of patients tapered from long\u2010term opioid therapy (LTOT) has increased in recent years in the United States. Some patients tapered from LTOT report improved quality of life, while others face increased risks of opioid\u2010related hospital use. Research has not yet established how the risk of opioid\u2010related hospital use changes across LTOT dose and subsequent tapering. Our objective was to examine associations between recent tapering from LTOT with odds of opioid\u2010related hospital use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2010crossover design using 2014\u20132018 health information exchange data from Indiana. We defined opioid\u2010related hospital use as hospitalizations, and emergency department (ED) visits for a drug overdose, opioid abuse, and dependence. We defined tapering as a 15% or greater dose reduction following at least 3\u2009months of continuous opioid therapy of 50 morphine milligram equivalents (MME)\/day or more. We used conditional logistic regression to estimate odds ratios (OR) with 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recent tapering from LTOT was associated with increased odds of opioid\u2010related hospital use (OR: 1.50, 95%CI: 1.34\u20131.63), ED visit (OR: 1.52; 95%CI: 1.35\u20131.72), and inpatient hospitalization (OR: 1.40; 95%CI: 1.20\u20131.65). We found no evidence of heterogeneity of the effect of tapering on opioid\u2010related hospital use by gender, age, and race. Recent tapering among patients on a high baseline dose (&gt;300\u2009MME) was associated with increased odds of opioid\u2010related hospital use (OR: 2.95, 95% CI: 2.12\u20134.11, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to patients on a lower baseline doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recent tapering from LTOT is associated with increased odds of opioid\u2010related hospital use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5581","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T15:49:53Z","timestamp":1670428193000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Recent tapering from long\u2010term opioid therapy and odds of opioid\u2010related hospital use"],"prefix":"10.1002","volume":"32","author":[{"given":"Olena","family":"Mazurenko","sequence":"first","affiliation":[{"name":"Richard M. Fairbanks School of Public Health Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Richard M. Fairbanks School of Public Health Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedha","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Liberal Arts IUPUI  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Harle","sequence":"additional","affiliation":[{"name":"Richard M. 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Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosali","family":"Simon","sequence":"additional","affiliation":[{"name":"Paul O'Neill School of Public and Environmental Affairs Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4278"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.23970\/AHRQEPCCER229"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6691"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.16409"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1904190"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.16271"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109108"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m283"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010019\u201005301\u20102"},{"key":"e_1_2_7_12_1","volume-title":"Evidence Brief: Benefits and Harms of Long\u2010Term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain","author":"Mackey K","year":"2019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.31478\/202008c"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4564"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10742\u2010020\u201000228\u20102"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11118"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2019.305412"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4366"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.24.5.1214"},{"key":"e_1_2_7_21_1","unstructured":"Centers for Disease Control and Prevention.Data resources: analyzing prescription data and morphine milligram equivalents (MMEs).2018. 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