{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:42Z","timestamp":1785451302556,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Investigate the association between anticholinergic (AC) and sedative (SED) drug burden before hospitalization and postdischarge institutionalization (PDI) in community\u2010dwelling older patients acutely admitted to hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study using data from the Norwegian Patient Registry and the Norwegian Prescription Database. We studied acutely hospitalized community\u2010dwelling patients \u226570\u2009years during 2013 (<jats:italic>N<\/jats:italic>\u00a0=\u00a086\u2009509). Patients acutely admitted to geriatric wards underwent subgroup analyses (<jats:italic>n<\/jats:italic>\u00a0=\u00a01715). We calculated drug burden by the Drug Burden Index (DBI), use of AC\/SED drugs, and the number of AC\/SED drugs. Piecewise linearity of DBI versus PDI and a knot point (DBI\u00a0=\u00a02.45) was identified. Statistical analyses included an adjusted multivariable logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the total population, 45.4% were exposed to at least one AC\/SED drug, compared to 52.5% in the geriatric subgroup. AC\/SED drugs were significantly associated with PDI. The DBI with odds ratios (ORs) of 1.11 (95% CI 1.07\u20131.15) for DBI\u2009&lt;\u20092.45 and 1.08 (95% CI 1.04\u20131.13) for DBI\u2009\u2265\u20092.45. The number of AC\/SED drugs with OR of 1.07 (95% CI 1.05\u20131.09). The AC component of DBI with OR 1.23 and the number of AC drugs with OR 1.13. In the subgroup, ORs were closer to 1 for AC drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of AC\/SED drugs was highly prevalent in older patients before acute hospital admissions, and significantly associated with PDI. The number, or just using AC\/SED drugs, gave similar associations with PDI compared to applying the DBI. Using AC drugs showed higher sensitivity, indicating that to reduce the risk of PDI, a clinical approach could be to reduce the number of AC drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5590","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T07:59:05Z","timestamp":1672473545000},"page":"607-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is anticholinergic and sedative drug burden associated with postdischarge institutionalization in community\u2010dwelling older patients acutely admitted to hospital? 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