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However, the duration of SSRI\u2010associated sexual adverse effects, and their possible persistence after treatment discontinuation, is still uncertain. The aims of the current systematic review were first to identify existing evidence of sexual dysfunction following SSRI discontinuation, and to provide an account of reported symptoms and proposed treatment options; and second, to establish whether current literature allows accurate estimates of the prevalence of such sexual dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted on PubMed, Embase, and Google Scholar; papers with clinical data regarding patients with persistent sexual dysfunction after SSRI treatment suspension were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, two retrospective interventional studies, six observational studies and 11 case reports were judged eligible for inclusion. It was not possible to determine reliable estimates of prevalence. Similarly, a cause\u2010effect relationship between SSRI exposure and persistent sexual impairment could not be ascertained. Nonetheless, the potential for continued sexual disturbances despite discontinuation could not be entirely ruled out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a need to investigate a possible dose\u2013response relationship between SSRI exposure and persistent sexual adverse effects. Treatment options for persistent dysfunctions remain limited, but novel therapeutic approaches may be required in order to address an otherwise neglected need for sexual well\u2010being.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5653","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T16:29:35Z","timestamp":1686328175000},"page":"1053-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Selective serotonin reuptake inhibitors, post\u2010treatment sexual dysfunction and persistent genital arousal disorder: A systematic review"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-5621","authenticated-orcid":false,"given":"Livio","family":"Tarchi","sequence":"first","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-0972","authenticated-orcid":false,"given":"Giuseppe Pierpaolo","family":"Merola","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-3252","authenticated-orcid":false,"given":"Ottone","family":"Baccaredda\u2010Boy","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2624-6490","authenticated-orcid":false,"given":"Francesca","family":"Arganini","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-7096","authenticated-orcid":false,"given":"Emanuele","family":"Cassioli","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-3879","authenticated-orcid":false,"given":"Eleonora","family":"Rossi","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-4221","authenticated-orcid":false,"given":"Mario","family":"Maggi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Excellence Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d University of Florence  Florence Italy"},{"name":"I.N.B.B. 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