{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:51:52Z","timestamp":1782604312941,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Liver injury after Covid\u201019 vaccine has been described, although the incidence was not well established. We aimed to compare cumulative incidence of new onset liver test alteration after Covid\u201019 vaccination, and to compare with an historical control of influenza vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study which included adults who received at least one dose of Covid\u201019 vaccine from January 1 to May 30, 2021 and a control group who received a single dose of influenza vaccine during 2019, in a tertiary medical center from Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 29\u2009798 patients in Covid\u201019 vaccine group and 24\u2009605 in influenza vaccine group. Liver function tests were performed in 7833 (26.9%) in Covid\u201019 vaccine group and 8459 (34.37%) in influenza vaccine group. Cumulative incidence at 90\u2009days of new onset liver enzyme test alteration was 4.7 per 1000 (95% 4.0\u20135.5) for Covid\u201019 group, and 5.1 per 1000 (95% 4.3\u20136.1) for the influenza vaccine group (<jats:italic>p<\/jats:italic> value\u2009=\u20090.489). Two patients in the Covid\u201019 vaccine group developed immune mediated liver injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found no difference in liver test alteration between groups. These findings support the safety of Covid\u201019 vaccines. While we have identified two cases that are consistent with immune mediated liver injury following COVID\u201019 vaccination, we believe that the available data is insufficient to attribute them solely to the vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5696","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T05:38:31Z","timestamp":1694842711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered liver function test after <scp>Covid<\/scp>\u201019 vaccines: A retrospective control group study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-8245","authenticated-orcid":false,"given":"Fernando Ezequiel","family":"Jabif","sequence":"first","affiliation":[{"name":"Internal Medicine Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Gabriel","family":"Vallone","sequence":"additional","affiliation":[{"name":"Internal Medicine Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina Cecilia","family":"Stanek","sequence":"additional","affiliation":[{"name":"Infectious Diseases Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene Padilla","family":"Lopez","sequence":"additional","affiliation":[{"name":"Hepatology Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sobenko","sequence":"additional","affiliation":[{"name":"Hepatology Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra Maria","family":"Villamil","sequence":"additional","affiliation":[{"name":"Hepatology Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florencia Grande","family":"Ratti","sequence":"additional","affiliation":[{"name":"Internal Medicine Section Hospital Italiano de Buenos Aires  Buenos Aires Argentina"},{"name":"Internal Medicine Research Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina CONICET Independent Research  Ciudad de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1224379"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30566\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000426\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"ChaiX HuL ZhangY et al.Specific ACE2 expression in cholangiocytes may cause liver damage after 2019\u2010nCoV infection. bioRxiv.2020. doi:10.1101\/2020.02.03.931766","DOI":"10.1101\/2020.02.03.931766"},{"key":"e_1_2_10_6_1","unstructured":"Swissmedic.Side Effects of COVID\u201019 Vaccines in Switzerland\u2014Update. 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