{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:52:50Z","timestamp":1785207170438,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to describe the implementation of a new retrospective Belgian national cohort of pregnant women, the Belgian Medication Exposure during Pregnancy (BeMeP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We linked the national dispensing data to birth and death certificates and hospital stay data for a 7\u2010year period between 2010 and 2016 for the first time in Belgium. We presented the characteristics of pregnancy events associated with the mothers enrolled in the linkage study. Next, we constructed a cohort of pregnancies and compared some characteristics computed using the BeMeP database with the national statistics. Finally, we described the use of medications during pregnancy based on the first level of the Anatomical Therapeutic Chemical (ATC) classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 630\u2009457 pregnant women with 900\u2009024 pregnancy\u2010related events (843\u2009780 livebirths, 1937 stillbirths, 6402 ectopic events, and 47\u2009905 abortions) linked to medication exposure information. Overall, 96.3% of live births and 83.5% of stillbirths (national statistics as reference) were captured from the BeMeP. During pregnancy, excluding the week of birth, 78.9% of live birth pregnancies and 79.6% of stillbirth pregnancies were exposed to at least one medication. The most frequently dispensed medications were anti\u2010infectives (ATC code J\u2009=\u200950.2%) for live births and for stillbirths (44.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We linked information on pregnancies, all reimbursed medications dispensed by community pharmacists, all medications dispensed during hospitalization, sociodemographic status, and infant health to create the BeMeP database. The database represents a valuable potential resource for studying exposure\u2010outcome associations for medication use during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5705","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:20:50Z","timestamp":1695946850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Belgian medication exposure during pregnancy (<scp>BeMeP<\/scp>), a new nationwide linked database: Linkage methods and prevalence of medication use"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-6788","authenticated-orcid":false,"given":"Lionel","family":"Larcin","sequence":"first","affiliation":[{"name":"Centre de recherche Epid\u00e9miologie, Biostatistique et Recherche Clinique, Ecole de sant\u00e9 publique Universit\u00e9 libre de Bruxelles (U.L.B.)  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Bruxelles Belgium"},{"name":"Competence Center for Methodology and Statistics Luxembourg Institute of Health  Strassen Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Damase\u2010Michel","sequence":"additional","affiliation":[{"name":"Pharmacologie M\u00e9dicale, Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse III  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fati","family":"Kirakoya\u2010Samadoulougou","sequence":"additional","affiliation":[{"name":"Centre de recherche Epid\u00e9miologie, Biostatistique et Recherche Clinique, Ecole de sant\u00e9 publique Universit\u00e9 libre de Bruxelles (U.L.B.)  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4789"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2005.14.104"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219095"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0647-2"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3613"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-037837"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2159"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1705"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093870"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067405"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5299"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4862"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5558"},{"key":"e_1_2_14_15_1","unstructured":"Comit\u00e9 de S\u00e9curit\u00e9 de l'information.D\u00e9lib\u00e9ration n\u00b020\/104 du 19 juin 2020 modifi\u00e9e le 11 janvier 2022. 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