{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:06:22Z","timestamp":1760385982324,"version":"3.41.2"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to identify opioid consumption trajectories among persons living with chronic pain (CP) and put them in relation to patient\u2010reported outcomes 6 months after initiating multidisciplinary pain treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study used data from the Quebec Pain Registry (2008\u20132014) linked to longitudinal Quebec health insurance databases. We included adults diagnosed with CP and covered by the Quebec public prescription drug insurance plan. The daily cumulative opioid doses in the first 6\u2009months after initiating multidisciplinary pain treatment were transformed into morphine milligram equivalents. An individual\u2010centered approach involving principal factor and cluster analyses applied to longitudinal statistical indicators of opioid use was conducted to classify trajectories. Multivariate regression models were applied to evaluate the associations between trajectory group membership and outcomes at 6\u2010month follow\u2010up (pain intensity, pain interference, depression, and physical and mental health\u2010related quality of life).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified three trajectories of opioid consumption: \u201cno or very low and stable\u201d opioid consumption (<jats:italic>n<\/jats:italic>\u2009=\u20092067, 96.3%), \u201cincreasing\u201d opioid consumption (<jats:italic>n<\/jats:italic>\u2009=\u200940, 1.9%), and \u201cdecreasing\u201d opioid consumption (<jats:italic>n<\/jats:italic>\u2009=\u200939, 1.8%). Patients in the \u201cno or very low and stable\u201d trajectory were less likely to be current smokers, experience polypharmacy, use opioids or benzodiazepine preceding their first visit, or experience pain interference at treatment initiation. Patients in the \u201cincreasing\u201d opioid consumption group had significantly greater depression scores at 6\u2010month compared to patients in the \u201cno or very low and stable\u201d trajectory group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Opioid consumption trajectories do not seem to be important determinants of most PROs 6\u2009months after initiating multidisciplinary pain treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5706","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:48:17Z","timestamp":1696614497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trajectories of opioid consumption as predictors of patient\u2010reported outcomes among individuals attending multidisciplinary pain treatment 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