{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:33Z","timestamp":1753869873429,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Our study examined the association between outpatient postsurgical analgesic prescription and risk of insufficiently managed pain characterized by pain\u2010associated hospital admission and emergency room (ER) visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible individuals were children 1\u201317\u2009years of age who filled an incident analgesic following an outpatient surgery during 2013\u20132018. Pain\u2010associated hospital admission or ER visit were measured within 30\u2009days following the outpatient surgical procedure. A hierarchical multivariable logistic regression model with patients nested under prescribers was fitted to test the association between incident analgesic prescription and risk of having pain\u2010associated hospital admission or ER visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 14\u2009277 children meeting the inclusion criteria, 6224 (43.6%) received an incident opioid and 8053 (56.4%) received an incident non\u2010opioid analgesic prescription respectively. There were a total of 523 (3.7%) children undergoing surgical procedures\u00a0that had pain\u2010related hospital admissions or ER visits with 5.1% initiated on non\u2010opioid analgesics and 1.8% on opioid analgesics. The multilevel model indicated that initial opioid analgesic recipients were 32% less likely of having a pain\u2010associated hospital admission or ER visit [aOR: 0.68 (95% CI: 0.3\u20130.8)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Majority of postsurgical patients do not require additional pain management strategies. In the 3.7% of patients requiring additional pain management strategies, those initiated on non\u2010opioid analgesics are more likely to have a pain\u2010associated hospital admission or ER visit compared with their opioid recipient counterparts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5759","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:00:01Z","timestamp":1707991201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain\u2010related hospitalization and emergency room visit following initial analgesic prescription after outpatient surgery"],"prefix":"10.1002","volume":"33","author":[{"given":"Abhishek A.","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Placencia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold J.","family":"Farber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Pulmonology Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajender R.","family":"Aparasu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020\u20100387"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20101364"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.5045"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20101906"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010017\u20104788\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aorn.2016.01.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010009\u20109169\u20108"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102044.2007.05248.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13993"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181ee8479"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s4554"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000579"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463717722119"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000160"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-201406001-00621"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000002238"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814549732"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017\u20102156"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.07.021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2137284"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31817a835d"},{"key":"e_1_2_10_24_1","unstructured":"EneM LeightonEA BlueGL BellBA.Multilevel models for categorical data using SAS\u00ae PROC GLIMMIX: the basics. 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