{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:33Z","timestamp":1753869873985,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Medication poisoning is the most common method of self\u2010harm. Longitudinal studies incorporating pre\u2010 and post\u2010COVID\u201019 pandemic data are required to describe the phenomenon and to evaluate the long\u2010term impact on mental health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Calls to the Poison Control Center of Policlinico Umberto I Hospital \u2010 Sapienza University of Rome, Italy, were analyzed retrospectively for characteristics and clinical presentation of cases of interest from January 2018 to December 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 756 cases of self\u2010harm by medication poisonings were recorded in the study period. A reduction in rate of cases in 2020 was followed by a return to pre\u2010pandemic levels by 2021. When separately analyzing single\u2010 and multi\u2010agent cases, occurrence of cases involving just one medication increased since early 2021, with a peak in 2022 (7.8% of total calls, 95% CI 6.2\u20139.5, from 4.9%, 95% CI 4.1\u20135.8 in 2018). This increase in the rate of cases, mostly of none or mild severity, was driven by youth aged 12\u201321, in which the relative proportion of single\u2010 versus multi\u2010agent cases showed an increasing trend since 2020 (from 42.6% in 2018 to 78.6% in 2022). Acetaminophen was the medication most frequently involved and benzodiazepines the largest class. A psychiatric background was increasingly seen in 2022, especially in age group 12\u201321.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010agent medication self\u2010harm may be an increasingly prevailing phenomenon. Young adolescents with a psychiatric background might be most vulnerable to this behavior in the COVID\u201019 pandemic aftermath. Healthcare professionals should expect favorable clinical outcome and improve both counseling and psychotherapy supervision in individuals at risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5767","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:04:20Z","timestamp":1707991460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self\u2010harm by single\u2010 and multi\u2010agent medication poisoning in a retrospective analysis of a Poison Control Center database from January 2018 to December 2022"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-8549","authenticated-orcid":false,"given":"Michele Stanislaw","family":"Milella","sequence":"first","affiliation":[{"name":"Poison Control Center Unit, Department of Emergency, Anesthesia and Critical Care Medicine Policlinico Umberto I Hospital \u2010 Sapienza, University of Rome  Rome Italy"},{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Petraccia","sequence":"additional","affiliation":[{"name":"Poison Control Center Unit, Department of Emergency, Anesthesia and Critical Care Medicine Policlinico Umberto I Hospital \u2010 Sapienza, University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pirelli","sequence":"additional","affiliation":[{"name":"Poison Control Center Unit, Department of Emergency, Anesthesia and Critical Care Medicine Policlinico Umberto I Hospital \u2010 Sapienza, University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Foti","sequence":"additional","affiliation":[{"name":"Poison Control Center Unit, Department of Emergency, Anesthesia and Critical Care Medicine Policlinico Umberto I Hospital \u2010 Sapienza, University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sapio","sequence":"additional","affiliation":[{"name":"Poison Control Center Unit, Department of Emergency, Anesthesia and Critical Care Medicine Policlinico Umberto I Hospital \u2010 Sapienza, University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Berardi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesia and Critical Care Medicine, Policlinico Umberto I Hospital\u2010Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. 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