{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:37Z","timestamp":1786978357419,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K08 AG071794"],"award-info":[{"award-number":["K08 AG071794"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG056479"],"award-info":[{"award-number":["R01 AG056479"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited research has evaluated the validity of claims\u2010based definitions for deprescribing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate the validity of claims\u2010based definitions of deprescribing against electronic health records (EHRs) for deprescribing of benzodiazepines (BZDs) after a fall\u2010related hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a novel data linkage between Medicare fee\u2010for\u2010service (FFS) and Part D with our health system's EHR. We identified patients aged \u226566\u2009years with a fall\u2010related hospitalization, continuous enrollment in Medicare FFS and Part D for 6\u2009months pre\u2010 and post\u2010hospitalization, and \u22652 BZD fills in the 6\u2009months pre\u2010hospitalization. Using a standardized EHR abstraction tool, we adjudicated deprescribing for a sub\u2010sample with a fall\u2010related hospitalization at UNC. We evaluated the validity of claims\u2010based deprescribing definitions (e.g., gaps in supply, dosage reductions) versus chart review using sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 257 patients in the overall sample, 44% were aged 66\u201374\u2009years, 35% had Medicare low\u2010income subsidy, 79% were female. Among claims\u2010based definitions using gaps in supply, the prevalence of BZD deprescribing ranged from 8.2% (no refills) to 36.6% (30\u2010day gap). When incorporating dosage, the prevalence ranged from 55.3% to 65.8%. Among the validation sub\u2010sample (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947), approximately one\u2010third had BZDs deprescribed in the EHR. Compared to EHR, gaps in supply from claims had good sensitivity, but poor specificity. Incorporating dosage increased sensitivity, but worsened specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The sensitivity of claims\u2010based definitions for deprescribing of BZDs was low; however, the specificity of a 90\u2010day gap was &gt;90%. Replication in other EHRs and for other low\u2010value medications is needed to guide future deprescribing research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.5784","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T02:05:30Z","timestamp":1711937130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validating claims\u2010based definitions for deprescribing: Bridging the gap between clinical and administrative data"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-5751","authenticated-orcid":false,"given":"Joshua D.","family":"Niznik","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine University of North Carolina at Chapel Hill, School of Medicine  Chapel Hill North Carolina USA"},{"name":"Center for Aging and Health University of North Carolina at Chapel Hill, School of Medicine  Chapel Hill North Carolina USA"},{"name":"Division of Pharmaceutical Outcomes and Policy University of North Carolina at Chapel Hill, Eshelman School of Pharmacy  Chapel Hill North Carolina USA"},{"name":"Center for Health Equity Research and Promotion Veterans Affairs (VA) Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-1875","authenticated-orcid":false,"given":"Shahar","family":"Shmuel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill, Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pate","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill, Gillings School of Global Public Health  Chapel Hill North Carolina 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