{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:30:38Z","timestamp":1786591838528,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the real\u2010world rates of non\u2010adherence and non\u2010persistence to antiretroviral therapy (ART) among treatment\u2010na\u00efve adult patients with HIV after a 12\u2010month follow\u2010up period in Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of longitudinal pharmacy claims was conducted using the Pharmanet database from January 1, 2018, to December 31, 2021. Non\u2010adherence was assessed over 12\u2009months and reported as the proportion of days covered below the 80% threshold. Non\u2010persistence was defined as the first 90\u2010day gap in treatment between the two types of ART dispensed. Poisson regression with robust standard error and Cox proportional hazard models were used to assess the factors associated with non\u2010adherence and non\u2010persistence, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 2999 patients were initiated on ART between 2018 and 2021. After a 12\u2010month follow\u2010up, the proportions of non\u2010adherence and non\u2010persistence were 35.6% and 15.9%, respectively in 2018, and decreased to 18.7% and 6.8%, respectively in 2021. Non\u2010adherence was higher among women, Brussels residents, and those receiving multiple\u2010tablet regimens (MTRs). Similarly, the prevalence of non\u2010persistence was higher among women and MTR recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among treatment\u2010na\u00efve adults with HIV in Belgium, non\u2010adherence, and non\u2010persistence to ART showed improvement over the study period but remained at high levels. Disparities were observed by sex and between geographical regions. Prioritizing strategies targeting women in Brussels and facilitating the transition from MTRs to single\u2010tablet regimens should be emphasized optimize adherence to ART in Belgium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.5804","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:09:13Z","timestamp":1715648953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010adherence and non\u2010persistence with antiretroviral treatment in Belgium: A real\u2010world evaluation using a pharmacy database, 2018\u20132021"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7004-1461","authenticated-orcid":false,"given":"Dieudonn\u00e9","family":"Ilboudo","sequence":"first","affiliation":[{"name":"Centre de recherche Epid\u00e9miologie, Biostatistique et Recherche Clinique, Ecole de sant\u00e9 publique Universit\u00e9 libre de Bruxelles (U.L.B.)  Bruxelles Belgium"},{"name":"District Sanitaire de Banfora, Direction R\u00e9gionale de la Sant\u00e9 des Cascades  Banfora Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7649-6201","authenticated-orcid":false,"given":"Patricia","family":"Mbouche","sequence":"additional","affiliation":[{"name":"Centre de recherche Epid\u00e9miologie, Biostatistique et Recherche Clinique, Ecole de sant\u00e9 publique Universit\u00e9 libre de Bruxelles (U.L.B.)  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-5650","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Sommet","sequence":"additional","affiliation":[{"name":"Pharmacologie M\u00e9dicale, Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse III, Inserm CERPOP, CHU  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-9340","authenticated-orcid":false,"given":"Philippe","family":"Van Wilder","sequence":"additional","affiliation":[{"name":"Centre de recherche en Economie de la Sant\u00e9, Gestion des Institutions de Soins et Sciences Infirmi\u00e8res, Ecole de Sant\u00e9 Publique Universit\u00e9 Libre de Bruxelles (ULB)  Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9584-6329","authenticated-orcid":false,"given":"Fati","family":"Kirakoya\u2010Samadoulougou","sequence":"additional","affiliation":[{"name":"Centre de recherche Epid\u00e9miologie, Biostatistique et Recherche Clinique, Ecole de sant\u00e9 publique Universit\u00e9 libre de Bruxelles (U.L.B.)  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