{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T16:27:59Z","timestamp":1700324879605},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,7,18]],"date-time":"2001-07-18T00:00:00Z","timestamp":995414400000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An international multicenter study entitled Collaborative Study on Drug Use in Pregnancy (DUP) was initiated in 1987 by the Mario Negri Institute (Milano) and co\u2010sponsored by the WHO Regional Office for Europe (Copenhagen). The study covered the use of medicines during pregnancy, labour and postpartum period. The Novi Sad centre contributed with 296 questionnaires. The aim of the study was to evaluate the pharmacotherapy by means of comparison, to identify problems in a particular settings and to plan actions toward improvement. The prescribing of some medicines in the Novi Sad center was found to be at the extreme, being among the lowest in the use of iron preparations during pregnancy and among the highest in the use of ergot alkaloids in the postpartum period. Educational efforts have been made to change this practice after the conclusion of the study in 1989. Ten years later, in 1999, the same questionnaire was applied to 100 women in the postpartum period in the same nursery, the Department of Obstetrics and Gynecology in Novi Sad. The results have shown a distinct improvement with the increase of iron prescribing during pregnancy and almost complete abandonment of postpartum use of ergot alkaloids. In the second study period some other inconsistencies with accepted therapeutical principles were identified. For example, although the use of analgesics fell from 22.3 to 8%, the selection changed towards the high use of metamizole (noraminophenazone) and no use of paracetamol (acetaminophen). It was concluded that international pharmacoepidemiological studies such as DUP, could substantially contribute to the improvement of pharmacotherapy if followed by appropriate actions in changing the prescribing behaviour of the physicians and information directed to the target population. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pds.585","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:49:13Z","timestamp":1030312153000},"page":"229-235","source":"Crossref","is-referenced-by-count":9,"title":["Collaborative study on drug use in pregnancy: the results of the follow\u2010up 10 years after (Novi Sad Centre)"],"prefix":"10.1002","volume":"10","author":[{"given":"A.","family":"Sabo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stanulovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Gruji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,18]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"MiglioD BonatiM AddisA et al.Cooperative study on drug use in pregnancy. Pregnant women and drugs. Final report Bergamo 1991."},{"key":"e_1_2_1_3_2","unstructured":"SaboA Stanulovi\u0107M Jakovljevi\u0107V.Drug use during puerperium and pregnancy. InInternational Meeting on Drug Use in Pregnancy and Puerperium. Bergamo 1997. Book of abstracts. No 34."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(92)90656-4"},{"key":"e_1_2_1_5_2","unstructured":"MathesonI PeenA.Drug use in puerperium. A comparison between obstetrics departments in Norway and other countries. InProceedings of the 12th Nordic Congress of Perinatal Medicine. Bergen1989;60."},{"key":"e_1_2_1_6_2","unstructured":"SaboA Andjeli\u0107M Jakovljevi\u0107V Stanulovi\u0107M.DUP study: improvement of pharmacotherapy: maternal part of the follow\u2010up study (Part II). InAbstracts of the Joint Meeting of VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR \u2013 Division of Clinical Pharmacology and 4th Congress of the European Association for Clinical; Pharmacology and Therapeutics (EACPT) Florence 15\u201320 July.394."},{"key":"e_1_2_1_7_2","unstructured":"SaboA Stanulovi\u0107M Andjeli\u0107M Jakovljevi\u0107V.DUP study: improvement of pharmacotherapy: newborn part of the follow\u2010up study (Part III) Abstracts of the Joint Meeting of VII World Conference on Clinical Pharmacology and Therapeutics IUPHAR \u2013 Division of Clinical Pharmacology and 4th Congress of the European Association for Clinical; Pharmacology and therapeutics (EACPT) Florence 15\u201320 July.395."},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Chronic medical disorders during pregnancy. 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