{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:24:25Z","timestamp":1777055065545,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2006957"],"award-info":[{"award-number":["APP2006957"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cardiovascular diseases are the leading cause of death globally. Ensuring ongoing use of medicines\u2014medication persistence\u2014is crucial, yet no prior studies have examined this in residential aged care facilities (RACFs). We aimed to identify long\u2010term trajectories of persistence with cardiovascular medicines and determine predictors of persistence trajectories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A longitudinal cohort study of 2837 newly admitted permanent residents from 30 RACFs in New South Wales, Australia. We monitored weekly exposure to six cardiovascular medicine classes\u2014lipid modifiers, angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers (ACEI\/ARBs), beta\u2010blockers, diuretics, calcium channel blockers (CCB), and cardiac therapy\u2014over 3\u2009years. Group\u2010based trajectory modeling was employed to determine persistence trajectories for each class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 76.6% (<jats:italic>n<\/jats:italic>\u2009=\u20092172) received at least one cardiovascular medicine with 41.2% receiving lipid modifiers, 31.4% ACEI\/ARBs, 30.2% beta\u2010blockers, 24.4% diuretics, 18.7% CCBs, and 14.8% cardiac therapy. The model identified two persistence trajectories for CCBs and three trajectories for all other classes. Sustained high persistence rates ranged from 68.4% (ACEI\/ARBs) to 79.8% (beta\u2010blockers) while early decline in persistence and subsequent discontinuation rates ranged from 7.6% (cardiac therapy) to 25.3% (CCBs). Logistic regressions identified 11 predictors of a declining persistence across the six medicine classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study revealed varied patterns of cardiovascular medicine use in RACFs, with 2\u20133 distinctive medicine use trajectories across different classes, each exhibiting a unique clinical profile, and up to a quarter of residents discontinuing a medicine class. Future studies should explore the underlying reasons and appropriateness of nonpersistence to aid in identifying areas for improvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.5881","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T03:53:44Z","timestamp":1722570824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Longitudinal Patterns and Predictors of Medicine Use in Residential Aged Care Using Group\u2010Based Trajectory Modeling: The \u201c<scp>MEDTRAC<\/scp>\u2010Cardiovascular\u201d Longitudinal Cohort Study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-6319","authenticated-orcid":false,"given":"Nasir","family":"Wabe","sequence":"first","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Timothy","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Urwin","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna\u00a0I.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Macquarie University  North Ryde New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_1113_22"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.12681"},{"key":"e_1_2_12_4_1","volume-title":"Older Australians","author":"Australian Institute of Health and Welfare","year":"2023"},{"key":"e_1_2_12_5_1","volume-title":"Heart, Stroke and Vascular Disease: Australian Facts","author":"Australian Institute of Health and Welfare","year":"2023"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104733.2007.00213.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14206"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006056"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.030264"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23898"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X253843"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010015\u20100245\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20101201"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.12.011"},{"key":"e_1_2_12_15_1","volume-title":"HIC 2010: Proceedings; 18th Annual Health Informatics Conference: Informing the Business of Healthcare","author":"Westbrook J.","year":"2010"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2020.26.9.1138"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.865"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512\u2010200926060\u201000007"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.01.013"},{"key":"e_1_2_12_20_1","first-page":"404","article-title":"Designing an Informatics Infrastructure for a National Aged Care Medication Roundtable","volume":"310","author":"Westbrook J. 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