{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:30:16Z","timestamp":1781523016479,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several cases of renal complications, including acute kidney injury (AKI), after influenza vaccination have been reported, but the association remains unproven. We evaluated the association between influenza vaccination and AKI occurrence among the Korean elderly in the 2018\u20132019 and 2019\u20132020 seasons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a large database combining vaccination registration data from the Korea Disease Control and Prevention Agency and claims data from the National Health Insurance Service. The study subjects were patients hospitalized with AKI for the first\u2010time following vaccination among those who received one influenza vaccine in the 2018\u20132019 or 2019\u20132020 season. Only those aged 65 or older at the date of vaccination were included. We performed a self\u2010controlled case series study, designating the risk period as 1 to 28\u2009days post\u2010vaccination and the observation period as each influenza season. The adjusted incidence rate ratio (aIRR) was calculated by adjusting for nephrotoxic drug use and influenza infection that may influence AKI occurrence using a conditional Poisson regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16\u2009713 and 16\u2009272 AKI events were identified during the 2018\u20132019 and 2019\u20132020 seasons, respectively. The aIRR for AKI was 0.83 (95% confidence interval [CI]\u2009=\u20090.79\u20130.87) in the 2018\u20132019 season. The aIRR for the 2019\u20132020 influenza season was similar to the 2018\u20132019 season (aIRR\u2009=\u20090.86; 95% CI\u2009=\u20090.82\u20130.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Influenza vaccination is associated with a lower risk of AKI in the elderly over 65. This evidence supports the recommendation of annual influenza vaccination for the elderly. Further studies are needed to determine the biological mechanisms linking the influenza vaccine and AKI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.70006","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:04:13Z","timestamp":1725609853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Influenza Vaccination and Acute Kidney Injury Among the Elderly: A Self\u2010Controlled Case Series"],"prefix":"10.1002","volume":"33","author":[{"given":"Haerin","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Health Convergence Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Health Convergence Ewha Womans University  Seoul Republic of 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