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We examined the incidence, practice variation and factors associated with new benzodiazepine and z\u2010drug community prescriptions among critical illness survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study using the UK Clinical Practice Research Datalink data included 52\u2009846 adult critical care survivors hospitalised in 2010 and 2018 who were not prescribed benzodiazepines or z\u2010drugs before hospitalisation. We performed multilevel multivariable logistic regression to assess patient factors associated with new (any prescription within 90\u2009days) and with new\u2010and\u2010persistent (2+ prescriptions within 180\u2009days) benzodiazepine or z\u2010drug prescribing, and to evaluate variation by primary care practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>5.2% (2769\/52846) of treatment\u2010na\u00efve survivors (95% CI 5.1\u20135.4) were prescribed a benzodiazepine or z\u2010drug, and 2.5% (1311\/52846) had new\u2010and\u2010persistent prescribing. A history of insomnia (adjusted OR 1.96; 95% CI 1.74\u20132.21), anxiety or depression (adjusted OR 1.40; 95% CI 1.28\u20131.53) and recent prescription opioid use (adjusted OR 1.47; 95% CI 1.34\u20131.61) were associated with new community prescription. Sex was not associated with new prescriptions and older patients were less likely to receive a prescription. 2.6% of the variation in new prescribing and 4.1% of the variation in new\u2010and\u2010persistent prescribing were attributable to the prescribing practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One in twenty critical illness survivors receive a new community benzodiazepine or z\u2010drug prescription. Further research is needed to understand where in the patient care pathway initiation occurs and the risk of adverse events in survivors of recent critical illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pds.70056","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:43:48Z","timestamp":1732736628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patient Characteristics and Practice Variation Associated With New Community Prescription of Benzodiazepine and z\u2010Drug Hypnotics After Critical Illness: A Retrospective Cohort Study Using the\n                    <scp>UK<\/scp>\n                    Clinical\u00a0Practice\u00a0Research Datalink"],"prefix":"10.1002","volume":"33","author":[{"given":"Elizabeth T.","family":"Mansi","sequence":"first","affiliation":[{"name":"Usher Institute University of Edinburgh  Edinburgh 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