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The aims of the GCFR are to optimise quality of care for CF at the centres, generate epidemiologic overviews, address research questions related to improved CF care, and inform caregivers, patients (aimed at patient empowerment), and health authorities and industry (aimed at care planning and pharmacovigilance). Established in 1995, the Registry has captured data on &gt;\u20099600 individuals with a combined total of more than 140 000 annual assessments with an estimated coverage rate of &gt;\u200990%. Patient data are collected after informed consent and confirmed diagnosis of CF, or a CFTR\u2010related disorder, or a screening\u2010positive inconclusive diagnosis of CF (i.e., CFSPID). The registry collects core, encounter, and annual health data. Data include demographics, anthropometrics, lung function, microbiology, CF\u2010specific complications and chronic medications, hospitalisations, demand\u2010oriented antibiotic therapies, and outcomes (death and transplants). 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