{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:49Z","timestamp":1753869889760,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21nf0101636","JP21lk0201701"],"award-info":[{"award-number":["JP21nf0101636","JP21lk0201701"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess adverse neurological risks following influenza vaccination in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a linked database of healthcare administrative claims data and vaccination records from an urban city in Japan (April 1, 2014, to March 31, 2020), we conducted an observational study utilizing a self\u2010controlled case series design. We identified individuals aged \u2265\u200965\u2009years who experienced adverse neurological outcomes, defined as hospitalizations related to epilepsy, paralysis, facial paralysis, neuralgia, neuritis, optic neuritis, migraine, extrapyramidal disorders, Guillain\u2013Barre syndrome, or narcolepsy. We used conditional Poisson regression to analyze within\u2010subject incidence rate ratios, comparing the risk of these outcomes during risk periods following influenza vaccination (0\u20136\u2009days and 7\u201329\u2009days after each vaccination) with nonvaccination periods. Our analysis was adjusted for age and season groups as time\u2010varying covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 3283 eligible individuals (men: 1643; mean [standard deviation] age: 76 [7.3] years). The incidence rate ratio for the outcome during the risk periods was 0.93 (95% confidence interval, 0.66\u20131.30) in risk period 1 (0\u20136\u2009days after vaccination) and 1.14 (0.96\u20131.35) in risk period 2 (7\u201329\u2009days after vaccination), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found no evidence that the risk of adverse neurological events was increased after influenza vaccination in older adults. These results may help reassure older adults who are hesitant to receive influenza vaccination because of concerns regarding adverse neurological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.70082","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T01:35:01Z","timestamp":1736300101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety Assessment of Influenza Vaccination for Neurological Outcomes Among Older Adults in Japan: A Self\u2010Controlled Case Series Study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-7396","authenticated-orcid":false,"given":"Mitsunori","family":"Ogawa","sequence":"first","affiliation":[{"name":"Interfaculty Initiative in Information Studies The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-0513","authenticated-orcid":false,"given":"Yoshinori","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Data Science, School of Data Science, Association of International Arts and Sciences Yokohama City University  Kanagawa Japan"},{"name":"Department of Biostatistics, School of Public Health, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukino","family":"Iida","sequence":"additional","affiliation":[{"name":"Graduate School of Interdisciplinary Information Studies The University of Tokyo  Tokyo Japan"},{"name":"Center for Innovative Clinical Medicine Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-0640","authenticated-orcid":false,"given":"Masao","family":"Iwagami","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Uemura","sequence":"additional","affiliation":[{"name":"Interfaculty Initiative in Information Studies The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Eat\u2010loss Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Michihata","sequence":"additional","affiliation":[{"name":"Cancer Prevention Center Chiba Cancer Center Research Institute  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology &amp; 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