{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:06:38Z","timestamp":1780344398392,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005943","name":"Klinisk Epidemiologisk Forskningsfond, Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Animal studies suggest that paroxetine, unlike other selective serotonin reuptake inhibitors (SSRIs), may attenuate post\u2010myocardial infarction (MI) heart failure. We examine the effectiveness of paroxetine versus non\u2010paroxetine SSRIs on the risk of post\u2010MI mortality and heart failure in a clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a nationwide population\u2010based cohort study based on Danish medical registries. Using an active comparator design, we compared the effectiveness of paroxetine with non\u2010paroxetine SSRI drugs on post\u2010MI outcomes. This included all patients hospitalized for MI in Denmark during 1995\u20132020 who had redeemed an SSRI prescription within 90\u2009days prior to admission and measured outcome variables after a 180\u2010day follow\u2010up period. We calculated cumulative incidences as a measure of risk and used Cox regression to compute hazard ratios (HRs) for all outcomes, adjusting for sex, age group, individual comorbidities, and comedications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 13\u2009053 patients receiving treatment with an SSRI at the time of hospital admission for MI. Cumulative incidences were lower for paroxetine SSRI users compared with non\u2010paroxetine SSRI users for all\u2010cause mortality (24.7% versus 33.8% (difference: \u22129.1% [95% CI: \u221212.4; \u22125.8])) and cardiovascular death (15.9% versus 22.7% (\u22126.8% [95% CI: \u22129.6; \u22124.0])), but not for heart failure (11.0% versus 11.8% (\u22120.7% [95% CI: \u22123.13; 1.65])). Adjusted hazard ratios (aHRs) showed no substantial differences for all\u2010cause mortality (aHR 0.9 [95% CI: 0.8\u20131.1]), cardiovascular death (aHR 0.9 [95% CI: 0.8\u20131.1]), or heart failure (aHR 1.0 [95% CI: 0.8\u20131.3]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Paroxetine was not associated with clinically significant improvement in post\u2010MI outcomes compared with non\u2010paroxetine SSRI drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.70141","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T07:09:09Z","timestamp":1743145749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Paroxetine Versus Non\u2010Paroxetine Selective Serotonin Reuptake Inhibitors on Mortality and Heart Failure Following Myocardial Infarction: An Active Comparator Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-0601","authenticated-orcid":false,"given":"Thomas Ravn","family":"Lassen","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Institute of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Medicine Randers Regional Hospital  Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Szentk\u00fati","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Institute of Clinical Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Sundb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital and Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Goedstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004046"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.87.3.755"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000055318.09997.1f"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.7.1866"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.5.392"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010017\u20100614\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20100789"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp\u20102012\u20100022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.02.024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749\u20103797(02)00439\u20107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.194605"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004137"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.9422"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S179083"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010014\u20109930\u20103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010012832"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37587"},{"issue":"35","key":"e_1_2_10_21_1","first-page":"5030","article-title":"Reliability of Death Certificates. 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