{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:59:23Z","timestamp":1755223163073,"version":"3.43.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2014896"],"award-info":[{"award-number":["APP2014896"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacoepidemiology and Drug"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Administrative medicine dispensing data often omit prescribed duration, which is important for research on adherence or other pharmacoepidemiological topics. While the reverse waiting time distribution (rWTD) method has been widely used to estimate prescribed durations, its accuracy in real\u2010world dispensing data is unknown. We assessed the performance of the rWTD method against the actual prescribed duration recorded in the Rotterdam Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>100\u2009725 antihypertensive (AHT) prescriptions from 2018 to 2019 were extracted from the Rotterdam Study's medicine data. Data were constructed into five scenarios with increasing variability in the number of medicines included and variations in prescribed duration. The rWTD with 10 random index dates with or without adjustment for the quantity of dispensed medicine was conducted in all scenarios. Relative differences and limit of agreement ratio based on Bland\u2013Altman analysis were used to examine agreement between estimated and actual prescribed durations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rWTD models without adjustment for the quantity of dispensed medicine performed well only in the most homogenous scenario. In scenarios with greater data variability, performance improved significantly when adjusted for the quantity of dispensed medicine. Relative difference decreased from \u2265\u200965% in models without covariates to \u2264\u200920% with covariates, and the limit of agreement ratio decreased from \u2265\u200936.8 in models without covariates to \u2264\u20095.3 with covariates. Stratification analysis by subclass of the AHT medicines provided similar results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study demonstrated that as data variability increased, the accuracy of the rWTD estimations decreased. However, the rWTD can produce good estimates (relative difference from 0% to 28%) of prescribed duration for AHT medicines, with the highest accuracy in the model adjusting for the quantity of dispensed medicine or stratification of the data with a relative difference less than 20% and the limit of agreement ratio less than 5.3 for the estimation at the 90th percentile of inter\u2010arrival density. Since this validation was limited to antihypertensive medicines, generalizing the finding to other chronic\u2010use medicines should be undertaken with caution.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pds.70164","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:59:41Z","timestamp":1748836781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimation of the Duration of Antihypertensive Prescriptions: Validation of a Data\u2010Driven Approach Using Rotterdam Study Data"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-9409","authenticated-orcid":false,"given":"Chau L. B.","family":"Ho","sequence":"first","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Youens","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"},{"name":"Cardiovascular Epidemiology Research Centre, School of Population and Global Health The University of Western Australia  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter P.","family":"Abhayaratna","sequence":"additional","affiliation":[{"name":"Canberra Health Services, ACT  Canberra Australia"},{"name":"School of Medicine and Psychology Australian National University  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max K.","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Institute for Health Research The University of Notre Dame Australia  Fremantle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Hughes","sequence":"additional","affiliation":[{"name":"Curtin Medical School Curtin University  Perth Australia"},{"name":"PainChek Ltd  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Moorin","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"},{"name":"School of Population and Global Health The University of Western Australia  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallie\u2010Anne","family":"Pearson","sequence":"additional","affiliation":[{"name":"School of Population Health University of New South Wales  Sydney Australia"},{"name":"The NHMRC Medicines Intelligence Centre of Research Excellence  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Preen","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia  Perth Australia"},{"name":"The NHMRC Medicines Intelligence Centre of Research Excellence  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikje","family":"Ruiter","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC \u2013 University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Internal Medicine Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christobel M.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia  Perth Australia"},{"name":"Melbourne Medical School The University of Melbourne  Melbourne Australia"},{"name":"The Royal Melbourne Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno H.","family":"Stricker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC \u2013 University Medical Centre  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Independent Cancer Consumer Advisor  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J. A.","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC \u2013 University Medical Centre  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"},{"name":"Medical School The University of Western Australia  Perth Australia"},{"name":"Fiona Stanley Hospital  Murdoch Australia"},{"name":"School of Medicine University of Tasmania  Hobart Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninh Thi","family":"Ha","sequence":"additional","affiliation":[{"name":"School of Population Health, Faculty of Health Sciences Curtin University  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.10.012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5567"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1293-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4872"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4091"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-015-0140-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4216"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-021-03188-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4114"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5026"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3459"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-020-00640-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00145007"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-080982"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199710000-00009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S148671"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5340"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4217"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221500"},{"volume-title":"Beginner's Guide to Using Pharmaceutical Benefits Scheme Data: Tips and Pitfalls","year":"2012","author":"Kemp A.","key":"e_1_2_12_22_1"},{"volume-title":"WTDTTT: Stata Module to Estimate Parameters of the Ordinary and Reverse Waiting Time Distribution (WTD) by Maximum Likelihood, Statistical Software Components S458265","year":"2016","author":"Nielsen K. 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